Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism

OBJECTIVE: Macrophages control tissue homeostasis and inflammation by sensing and responding to environmental cues. However, the metabolic adaptation of macrophages to oxidative tissue damage and its translation into inflammatory mechanisms remains enigmatic. METHODS: Here we identify the critical r...

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Detalles Bibliográficos
Autores principales: Serbulea, Vlad, Upchurch, Clint M., Ahern, Katelyn W., Bories, Gael, Voigt, Paxton, DeWeese, Dory E., Meher, Akshaya K., Harris, Thurl E., Leitinger, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784323/
https://www.ncbi.nlm.nih.gov/pubmed/29153923
http://dx.doi.org/10.1016/j.molmet.2017.11.002

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