Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance

OBJECTIVE: Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway that produces nicotinamide adenine dinucleotide (NAD(+)), an essential co-substrate regulating a myriad of signaling pathways. We produced a mouse that overexpressed NAMPT in skeletal muscle...

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Detalles Bibliográficos
Autores principales: Costford, Sheila R., Brouwers, Bram, Hopf, Meghan E., Sparks, Lauren M., Dispagna, Mauro, Gomes, Ana P., Cornnell, Heather H., Petucci, Chris, Phelan, Peter, Xie, Hui, Yi, Fanchao, Walter, Glenn A., Osborne, Timothy F., Sinclair, David A., Mynatt, Randall L., Ayala, Julio E., Gardell, Stephen J., Smith, Steven R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784330/
https://www.ncbi.nlm.nih.gov/pubmed/29146412
http://dx.doi.org/10.1016/j.molmet.2017.10.012

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