Cargando…
Martrilin-3 (MATN3) Overexpression in Gastric Adenocarcinoma and its Prognostic Significance
BACKGROUND: The aim of this study was to investigate the expression level of martrilin-3 (MATN3) in patients with gastric adenocarcinoma (GAC) and to investigate the prognostic significance of MATN3. MATERIAL/METHODS: Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) data were used to...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784332/ https://www.ncbi.nlm.nih.gov/pubmed/29343680 http://dx.doi.org/10.12659/MSM.908447 |
_version_ | 1783295429361795072 |
---|---|
author | Wu, Ping-Li He, Yi-Fu Yao, Han-Hui Hu, Bing |
author_facet | Wu, Ping-Li He, Yi-Fu Yao, Han-Hui Hu, Bing |
author_sort | Wu, Ping-Li |
collection | PubMed |
description | BACKGROUND: The aim of this study was to investigate the expression level of martrilin-3 (MATN3) in patients with gastric adenocarcinoma (GAC) and to investigate the prognostic significance of MATN3. MATERIAL/METHODS: Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) data were used to predict the expression and prognostic value of MATN3 mRNA in GAC patients. Seventy-six GAC patients had GAC tissue samples and paired adjacent normal tissue samples collected retrospectively to examine the MATN3 protein expression level by immunohistochemical staining. Furthermore, Kaplan-Meier univariate and Cox multivariate analyses were used to verify the correlation between MATN3 expression and clinicopathological parameters of GAC patients and the prognostic significance of MATN3. RESULTS: The GEO and TCGA data predicted that MATN3 mRNA levels were significantly higher in GAC tissue compared to normal tissue (all p<0.05). Further survival analyses showed that GAC patients with high mRNA expression of MATN3 had significantly lower disease-free survival (DFS) and overall survival (OS) time than those with low mRNA expression of MATN3 (all p<0.05). Subsequent immunohistochemical staining results confirmed that the MATN3 protein levels in GAC tissues were highly expressed (p=0.000) compared to normal tissues. In addition, GAC patients with high protein expression of MATN3 had remarkably decreased OS compared to patients with low protein expression of MATN3 (p=0.000). Univariate and multivariate survival analyses revealed that MATN3 high expression could be used as an independent predictor of poor prognosis in GAC patients (all p=0.000). CONCLUSIONS: This study confirmed that MATN3 protein was highly expressed in GAC patients, and MATN3 overexpression could be used as an independent predictor of poor prognosis in GAC patients. |
format | Online Article Text |
id | pubmed-5784332 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57843322018-01-31 Martrilin-3 (MATN3) Overexpression in Gastric Adenocarcinoma and its Prognostic Significance Wu, Ping-Li He, Yi-Fu Yao, Han-Hui Hu, Bing Med Sci Monit Lab/In Vitro Research BACKGROUND: The aim of this study was to investigate the expression level of martrilin-3 (MATN3) in patients with gastric adenocarcinoma (GAC) and to investigate the prognostic significance of MATN3. MATERIAL/METHODS: Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) data were used to predict the expression and prognostic value of MATN3 mRNA in GAC patients. Seventy-six GAC patients had GAC tissue samples and paired adjacent normal tissue samples collected retrospectively to examine the MATN3 protein expression level by immunohistochemical staining. Furthermore, Kaplan-Meier univariate and Cox multivariate analyses were used to verify the correlation between MATN3 expression and clinicopathological parameters of GAC patients and the prognostic significance of MATN3. RESULTS: The GEO and TCGA data predicted that MATN3 mRNA levels were significantly higher in GAC tissue compared to normal tissue (all p<0.05). Further survival analyses showed that GAC patients with high mRNA expression of MATN3 had significantly lower disease-free survival (DFS) and overall survival (OS) time than those with low mRNA expression of MATN3 (all p<0.05). Subsequent immunohistochemical staining results confirmed that the MATN3 protein levels in GAC tissues were highly expressed (p=0.000) compared to normal tissues. In addition, GAC patients with high protein expression of MATN3 had remarkably decreased OS compared to patients with low protein expression of MATN3 (p=0.000). Univariate and multivariate survival analyses revealed that MATN3 high expression could be used as an independent predictor of poor prognosis in GAC patients (all p=0.000). CONCLUSIONS: This study confirmed that MATN3 protein was highly expressed in GAC patients, and MATN3 overexpression could be used as an independent predictor of poor prognosis in GAC patients. International Scientific Literature, Inc. 2018-01-18 /pmc/articles/PMC5784332/ /pubmed/29343680 http://dx.doi.org/10.12659/MSM.908447 Text en © Med Sci Monit, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Lab/In Vitro Research Wu, Ping-Li He, Yi-Fu Yao, Han-Hui Hu, Bing Martrilin-3 (MATN3) Overexpression in Gastric Adenocarcinoma and its Prognostic Significance |
title | Martrilin-3 (MATN3) Overexpression in Gastric Adenocarcinoma and its Prognostic Significance |
title_full | Martrilin-3 (MATN3) Overexpression in Gastric Adenocarcinoma and its Prognostic Significance |
title_fullStr | Martrilin-3 (MATN3) Overexpression in Gastric Adenocarcinoma and its Prognostic Significance |
title_full_unstemmed | Martrilin-3 (MATN3) Overexpression in Gastric Adenocarcinoma and its Prognostic Significance |
title_short | Martrilin-3 (MATN3) Overexpression in Gastric Adenocarcinoma and its Prognostic Significance |
title_sort | martrilin-3 (matn3) overexpression in gastric adenocarcinoma and its prognostic significance |
topic | Lab/In Vitro Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784332/ https://www.ncbi.nlm.nih.gov/pubmed/29343680 http://dx.doi.org/10.12659/MSM.908447 |
work_keys_str_mv | AT wupingli martrilin3matn3overexpressioningastricadenocarcinomaanditsprognosticsignificance AT heyifu martrilin3matn3overexpressioningastricadenocarcinomaanditsprognosticsignificance AT yaohanhui martrilin3matn3overexpressioningastricadenocarcinomaanditsprognosticsignificance AT hubing martrilin3matn3overexpressioningastricadenocarcinomaanditsprognosticsignificance |