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Intensive Communicative Therapy Reduces Symptoms of Depression in Chronic Nonfluent Aphasia

Background. Patients with brain lesions and resultant chronic aphasia frequently suffer from depression. However, no effective interventions are available to target neuropsychiatric symptoms in patients with aphasia who have severe language and communication deficits. Objective. The present study ai...

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Autores principales: Mohr, Bettina, Stahl, Benjamin, Berthier, Marcelo L., Pulvermüller, Friedemann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784455/
https://www.ncbi.nlm.nih.gov/pubmed/29192534
http://dx.doi.org/10.1177/1545968317744275
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author Mohr, Bettina
Stahl, Benjamin
Berthier, Marcelo L.
Pulvermüller, Friedemann
author_facet Mohr, Bettina
Stahl, Benjamin
Berthier, Marcelo L.
Pulvermüller, Friedemann
author_sort Mohr, Bettina
collection PubMed
description Background. Patients with brain lesions and resultant chronic aphasia frequently suffer from depression. However, no effective interventions are available to target neuropsychiatric symptoms in patients with aphasia who have severe language and communication deficits. Objective. The present study aimed to investigate the efficacy of 2 different methods of speech and language therapy in reducing symptoms of depression in aphasia on the Beck Depression Inventory (BDI) using secondary analysis (BILAT-1 trial). Methods. In a crossover randomized controlled trial, 18 participants with chronic nonfluent aphasia following left-hemispheric brain lesions were assigned to 2 consecutive treatments: (1) intensive language-action therapy (ILAT), emphasizing communicative language use in social interaction, and (2) intensive naming therapy (INT), an utterance-centered standard method. Patients were randomly assigned to 2 groups, receiving both treatments in counterbalanced order. Both interventions were applied for 3.5 hours daily over a period of 6 consecutive working days. Outcome measures included depression scores on the BDI and a clinical language test (Aachen Aphasia Test). Results. Patients showed a significant decrease in symptoms of depression after ILAT but not after INT, which paralleled changes on clinical language tests. Treatment-induced decreases in depression scores persisted when controlling for individual changes in language performance. Conclusions. Intensive training of behaviorally relevant verbal communication in social interaction might help reduce symptoms of depression in patients with chronic nonfluent aphasia.
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spelling pubmed-57844552018-02-05 Intensive Communicative Therapy Reduces Symptoms of Depression in Chronic Nonfluent Aphasia Mohr, Bettina Stahl, Benjamin Berthier, Marcelo L. Pulvermüller, Friedemann Neurorehabil Neural Repair Original Research Articles Background. Patients with brain lesions and resultant chronic aphasia frequently suffer from depression. However, no effective interventions are available to target neuropsychiatric symptoms in patients with aphasia who have severe language and communication deficits. Objective. The present study aimed to investigate the efficacy of 2 different methods of speech and language therapy in reducing symptoms of depression in aphasia on the Beck Depression Inventory (BDI) using secondary analysis (BILAT-1 trial). Methods. In a crossover randomized controlled trial, 18 participants with chronic nonfluent aphasia following left-hemispheric brain lesions were assigned to 2 consecutive treatments: (1) intensive language-action therapy (ILAT), emphasizing communicative language use in social interaction, and (2) intensive naming therapy (INT), an utterance-centered standard method. Patients were randomly assigned to 2 groups, receiving both treatments in counterbalanced order. Both interventions were applied for 3.5 hours daily over a period of 6 consecutive working days. Outcome measures included depression scores on the BDI and a clinical language test (Aachen Aphasia Test). Results. Patients showed a significant decrease in symptoms of depression after ILAT but not after INT, which paralleled changes on clinical language tests. Treatment-induced decreases in depression scores persisted when controlling for individual changes in language performance. Conclusions. Intensive training of behaviorally relevant verbal communication in social interaction might help reduce symptoms of depression in patients with chronic nonfluent aphasia. SAGE Publications 2017-12-01 2017-12 /pmc/articles/PMC5784455/ /pubmed/29192534 http://dx.doi.org/10.1177/1545968317744275 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Articles
Mohr, Bettina
Stahl, Benjamin
Berthier, Marcelo L.
Pulvermüller, Friedemann
Intensive Communicative Therapy Reduces Symptoms of Depression in Chronic Nonfluent Aphasia
title Intensive Communicative Therapy Reduces Symptoms of Depression in Chronic Nonfluent Aphasia
title_full Intensive Communicative Therapy Reduces Symptoms of Depression in Chronic Nonfluent Aphasia
title_fullStr Intensive Communicative Therapy Reduces Symptoms of Depression in Chronic Nonfluent Aphasia
title_full_unstemmed Intensive Communicative Therapy Reduces Symptoms of Depression in Chronic Nonfluent Aphasia
title_short Intensive Communicative Therapy Reduces Symptoms of Depression in Chronic Nonfluent Aphasia
title_sort intensive communicative therapy reduces symptoms of depression in chronic nonfluent aphasia
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784455/
https://www.ncbi.nlm.nih.gov/pubmed/29192534
http://dx.doi.org/10.1177/1545968317744275
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