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Mounting of Biomaterials for Use in Ophthalmic Cell Therapies

When used as scaffolds for cell therapies, biomaterials often present basic handling and logistical problems for scientists and surgeons alike. The quest for an appropriate mounting device for biomaterials is therefore a significant and common problem. In this review, we provide a detailed overview...

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Detalles Bibliográficos
Autores principales: Harkin, Damien G., Dunphy, Siobhan E., Shadforth, Audra M. A., Dawson, Rebecca A., Walshe, Jennifer, Zakaria, Nadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784520/
https://www.ncbi.nlm.nih.gov/pubmed/29338382
http://dx.doi.org/10.1177/0963689717723638
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author Harkin, Damien G.
Dunphy, Siobhan E.
Shadforth, Audra M. A.
Dawson, Rebecca A.
Walshe, Jennifer
Zakaria, Nadia
author_facet Harkin, Damien G.
Dunphy, Siobhan E.
Shadforth, Audra M. A.
Dawson, Rebecca A.
Walshe, Jennifer
Zakaria, Nadia
author_sort Harkin, Damien G.
collection PubMed
description When used as scaffolds for cell therapies, biomaterials often present basic handling and logistical problems for scientists and surgeons alike. The quest for an appropriate mounting device for biomaterials is therefore a significant and common problem. In this review, we provide a detailed overview of the factors to consider when choosing an appropriate mounting device including those experienced during cell culture, quality assurance, and surgery. By way of example, we draw upon our combined experience in developing epithelial cell therapies for the treatment of eye diseases. We discuss commercially available options for achieving required goals and provide a detailed analysis of 4 experimental designs developed within our respective laboratories in Australia, the United Kingdom, and Belgium.
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spelling pubmed-57845202018-01-30 Mounting of Biomaterials for Use in Ophthalmic Cell Therapies Harkin, Damien G. Dunphy, Siobhan E. Shadforth, Audra M. A. Dawson, Rebecca A. Walshe, Jennifer Zakaria, Nadia Cell Transplant Original Articles When used as scaffolds for cell therapies, biomaterials often present basic handling and logistical problems for scientists and surgeons alike. The quest for an appropriate mounting device for biomaterials is therefore a significant and common problem. In this review, we provide a detailed overview of the factors to consider when choosing an appropriate mounting device including those experienced during cell culture, quality assurance, and surgery. By way of example, we draw upon our combined experience in developing epithelial cell therapies for the treatment of eye diseases. We discuss commercially available options for achieving required goals and provide a detailed analysis of 4 experimental designs developed within our respective laboratories in Australia, the United Kingdom, and Belgium. SAGE Publications 2018-01-16 2017-11 /pmc/articles/PMC5784520/ /pubmed/29338382 http://dx.doi.org/10.1177/0963689717723638 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Harkin, Damien G.
Dunphy, Siobhan E.
Shadforth, Audra M. A.
Dawson, Rebecca A.
Walshe, Jennifer
Zakaria, Nadia
Mounting of Biomaterials for Use in Ophthalmic Cell Therapies
title Mounting of Biomaterials for Use in Ophthalmic Cell Therapies
title_full Mounting of Biomaterials for Use in Ophthalmic Cell Therapies
title_fullStr Mounting of Biomaterials for Use in Ophthalmic Cell Therapies
title_full_unstemmed Mounting of Biomaterials for Use in Ophthalmic Cell Therapies
title_short Mounting of Biomaterials for Use in Ophthalmic Cell Therapies
title_sort mounting of biomaterials for use in ophthalmic cell therapies
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784520/
https://www.ncbi.nlm.nih.gov/pubmed/29338382
http://dx.doi.org/10.1177/0963689717723638
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