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Predictors of abnormal cytology among HPV-infected women in remote territories of French Guiana

BACKGROUND: Cervical cancer prevention using cervical cytology is insufficiently sensitive, a significant proportion of HPV-infected women having normal cytology. The objective of the present study was to try to identify factors associated with abnormal cytology in HPV-infected women living in remot...

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Autores principales: Adenis, Antoine, Dufit, Valentin, Douine, Maylis, Ponty, Jerome, Bianco, Laure, Najioullah, Fatiha, Kilié, Odile, Catherine, Dominique, Thomas, Nadia, Deshayes, Jean Luc, Brousse, Paul, Carles, Gabriel, Grenier, Claire, Lacoste, Vincent, Molinie, Vincent, Cesaire, Raymond, Nacher, Mathieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784667/
https://www.ncbi.nlm.nih.gov/pubmed/29368607
http://dx.doi.org/10.1186/s12905-017-0493-9
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author Adenis, Antoine
Dufit, Valentin
Douine, Maylis
Ponty, Jerome
Bianco, Laure
Najioullah, Fatiha
Kilié, Odile
Catherine, Dominique
Thomas, Nadia
Deshayes, Jean Luc
Brousse, Paul
Carles, Gabriel
Grenier, Claire
Lacoste, Vincent
Molinie, Vincent
Cesaire, Raymond
Nacher, Mathieu
author_facet Adenis, Antoine
Dufit, Valentin
Douine, Maylis
Ponty, Jerome
Bianco, Laure
Najioullah, Fatiha
Kilié, Odile
Catherine, Dominique
Thomas, Nadia
Deshayes, Jean Luc
Brousse, Paul
Carles, Gabriel
Grenier, Claire
Lacoste, Vincent
Molinie, Vincent
Cesaire, Raymond
Nacher, Mathieu
author_sort Adenis, Antoine
collection PubMed
description BACKGROUND: Cervical cancer prevention using cervical cytology is insufficiently sensitive, a significant proportion of HPV-infected women having normal cytology. The objective of the present study was to try to identify factors associated with abnormal cytology in HPV-infected women living in remote areas of French Guiana. METHODS: A study was conducted in women aged 20–65 years having HPV infections confirmed by HPV DNA detection using the GREINER-BIO-ONE kit. In addition to HPV testing, cytology was performed and classified as normal or abnormal. Demographic and life history variables, and infecting genotypes were compared between the normal and abnormal cytology groups. RESULTS: None of the demographic and life history variables were associated with cytology results. HPV genotype 53 was significantly associated with absence of cytological abnormalities whereas HPV 52, 58, 16 and perhaps 33 and 66 were independently associated with a greater risk of cytological abnormalities. When grouping HPV genotypes in different species, only species 9 (HPV 16, 31, 33, 35, 52, 58, 67) was significantly associated with abnormal cytology AOR = 5.1 (95% CI = 2.3–11.2), P < 0.001. CONCLUSIONS: It was not possible to predict which HPV-infected women will have cytological abnormalities or notfrom anamnesis. In this study HPV 53 seemed more benign than other HPV genotypes. On the contrary, species n°9, containing 5 of the genotypes contained in the nonavalent HPV vaccine, was significantly associated with more cytological abnormalities. HPV testing and vaccination with the nonavalent vaccine should be implemented in these remote parts of French Guiana.
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spelling pubmed-57846672018-02-07 Predictors of abnormal cytology among HPV-infected women in remote territories of French Guiana Adenis, Antoine Dufit, Valentin Douine, Maylis Ponty, Jerome Bianco, Laure Najioullah, Fatiha Kilié, Odile Catherine, Dominique Thomas, Nadia Deshayes, Jean Luc Brousse, Paul Carles, Gabriel Grenier, Claire Lacoste, Vincent Molinie, Vincent Cesaire, Raymond Nacher, Mathieu BMC Womens Health Research Article BACKGROUND: Cervical cancer prevention using cervical cytology is insufficiently sensitive, a significant proportion of HPV-infected women having normal cytology. The objective of the present study was to try to identify factors associated with abnormal cytology in HPV-infected women living in remote areas of French Guiana. METHODS: A study was conducted in women aged 20–65 years having HPV infections confirmed by HPV DNA detection using the GREINER-BIO-ONE kit. In addition to HPV testing, cytology was performed and classified as normal or abnormal. Demographic and life history variables, and infecting genotypes were compared between the normal and abnormal cytology groups. RESULTS: None of the demographic and life history variables were associated with cytology results. HPV genotype 53 was significantly associated with absence of cytological abnormalities whereas HPV 52, 58, 16 and perhaps 33 and 66 were independently associated with a greater risk of cytological abnormalities. When grouping HPV genotypes in different species, only species 9 (HPV 16, 31, 33, 35, 52, 58, 67) was significantly associated with abnormal cytology AOR = 5.1 (95% CI = 2.3–11.2), P < 0.001. CONCLUSIONS: It was not possible to predict which HPV-infected women will have cytological abnormalities or notfrom anamnesis. In this study HPV 53 seemed more benign than other HPV genotypes. On the contrary, species n°9, containing 5 of the genotypes contained in the nonavalent HPV vaccine, was significantly associated with more cytological abnormalities. HPV testing and vaccination with the nonavalent vaccine should be implemented in these remote parts of French Guiana. BioMed Central 2018-01-24 /pmc/articles/PMC5784667/ /pubmed/29368607 http://dx.doi.org/10.1186/s12905-017-0493-9 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Adenis, Antoine
Dufit, Valentin
Douine, Maylis
Ponty, Jerome
Bianco, Laure
Najioullah, Fatiha
Kilié, Odile
Catherine, Dominique
Thomas, Nadia
Deshayes, Jean Luc
Brousse, Paul
Carles, Gabriel
Grenier, Claire
Lacoste, Vincent
Molinie, Vincent
Cesaire, Raymond
Nacher, Mathieu
Predictors of abnormal cytology among HPV-infected women in remote territories of French Guiana
title Predictors of abnormal cytology among HPV-infected women in remote territories of French Guiana
title_full Predictors of abnormal cytology among HPV-infected women in remote territories of French Guiana
title_fullStr Predictors of abnormal cytology among HPV-infected women in remote territories of French Guiana
title_full_unstemmed Predictors of abnormal cytology among HPV-infected women in remote territories of French Guiana
title_short Predictors of abnormal cytology among HPV-infected women in remote territories of French Guiana
title_sort predictors of abnormal cytology among hpv-infected women in remote territories of french guiana
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784667/
https://www.ncbi.nlm.nih.gov/pubmed/29368607
http://dx.doi.org/10.1186/s12905-017-0493-9
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