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Crowdsourced Asparagus Urinary Odor Population Kinetics

The consumption of asparagus is associated with the production of malodorous urine with considerable interindividual variability (IIV). To characterize the urinary odor kinetics after consumption of asparagus spears, we conducted a study with consenting attendees from two American Society for Clinic...

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Autores principales: Ramamoorthy, Anuradha, Sadler, Brian M., van Hasselt, J.G. Coen, Elassaiss‐Schaap, Jeroen, Kasichayanula, Sreeneeranj, Edwards, Alena Y., van der Graaf, Piet H., Zhang, Lei, Wagner, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784735/
https://www.ncbi.nlm.nih.gov/pubmed/29239147
http://dx.doi.org/10.1002/psp4.12264
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author Ramamoorthy, Anuradha
Sadler, Brian M.
van Hasselt, J.G. Coen
Elassaiss‐Schaap, Jeroen
Kasichayanula, Sreeneeranj
Edwards, Alena Y.
van der Graaf, Piet H.
Zhang, Lei
Wagner, John A.
author_facet Ramamoorthy, Anuradha
Sadler, Brian M.
van Hasselt, J.G. Coen
Elassaiss‐Schaap, Jeroen
Kasichayanula, Sreeneeranj
Edwards, Alena Y.
van der Graaf, Piet H.
Zhang, Lei
Wagner, John A.
author_sort Ramamoorthy, Anuradha
collection PubMed
description The consumption of asparagus is associated with the production of malodorous urine with considerable interindividual variability (IIV). To characterize the urinary odor kinetics after consumption of asparagus spears, we conducted a study with consenting attendees from two American Society for Clinical Pharmacology and Therapeutics (ASCPT) meetings. Subjects were randomized to eat a specific number of asparagus spears, and then asked to report their urinary odor perception. Eighty‐seven subjects were included in the final analysis. A mixed effect proportional odds model was developed that adequately characterized the dose‐response relationship. We estimated the half‐life of the asparagus effect on malodorous urine to be 4.7 hours (relative standard error (RSE) = 13.2%), and identified a dose‐response slope term with good precision (24.3%). Age was found as the predictor of IIV in slope estimates. This study design and tools can be used as a demonstration “crowdsourcing” project for studying population kinetics in organizational and educational settings.
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spelling pubmed-57847352018-02-07 Crowdsourced Asparagus Urinary Odor Population Kinetics Ramamoorthy, Anuradha Sadler, Brian M. van Hasselt, J.G. Coen Elassaiss‐Schaap, Jeroen Kasichayanula, Sreeneeranj Edwards, Alena Y. van der Graaf, Piet H. Zhang, Lei Wagner, John A. CPT Pharmacometrics Syst Pharmacol Original Articles The consumption of asparagus is associated with the production of malodorous urine with considerable interindividual variability (IIV). To characterize the urinary odor kinetics after consumption of asparagus spears, we conducted a study with consenting attendees from two American Society for Clinical Pharmacology and Therapeutics (ASCPT) meetings. Subjects were randomized to eat a specific number of asparagus spears, and then asked to report their urinary odor perception. Eighty‐seven subjects were included in the final analysis. A mixed effect proportional odds model was developed that adequately characterized the dose‐response relationship. We estimated the half‐life of the asparagus effect on malodorous urine to be 4.7 hours (relative standard error (RSE) = 13.2%), and identified a dose‐response slope term with good precision (24.3%). Age was found as the predictor of IIV in slope estimates. This study design and tools can be used as a demonstration “crowdsourcing” project for studying population kinetics in organizational and educational settings. John Wiley and Sons Inc. 2017-12-14 2018-01 /pmc/articles/PMC5784735/ /pubmed/29239147 http://dx.doi.org/10.1002/psp4.12264 Text en © 2017 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Ramamoorthy, Anuradha
Sadler, Brian M.
van Hasselt, J.G. Coen
Elassaiss‐Schaap, Jeroen
Kasichayanula, Sreeneeranj
Edwards, Alena Y.
van der Graaf, Piet H.
Zhang, Lei
Wagner, John A.
Crowdsourced Asparagus Urinary Odor Population Kinetics
title Crowdsourced Asparagus Urinary Odor Population Kinetics
title_full Crowdsourced Asparagus Urinary Odor Population Kinetics
title_fullStr Crowdsourced Asparagus Urinary Odor Population Kinetics
title_full_unstemmed Crowdsourced Asparagus Urinary Odor Population Kinetics
title_short Crowdsourced Asparagus Urinary Odor Population Kinetics
title_sort crowdsourced asparagus urinary odor population kinetics
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784735/
https://www.ncbi.nlm.nih.gov/pubmed/29239147
http://dx.doi.org/10.1002/psp4.12264
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