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Crowdsourced Asparagus Urinary Odor Population Kinetics
The consumption of asparagus is associated with the production of malodorous urine with considerable interindividual variability (IIV). To characterize the urinary odor kinetics after consumption of asparagus spears, we conducted a study with consenting attendees from two American Society for Clinic...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784735/ https://www.ncbi.nlm.nih.gov/pubmed/29239147 http://dx.doi.org/10.1002/psp4.12264 |
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author | Ramamoorthy, Anuradha Sadler, Brian M. van Hasselt, J.G. Coen Elassaiss‐Schaap, Jeroen Kasichayanula, Sreeneeranj Edwards, Alena Y. van der Graaf, Piet H. Zhang, Lei Wagner, John A. |
author_facet | Ramamoorthy, Anuradha Sadler, Brian M. van Hasselt, J.G. Coen Elassaiss‐Schaap, Jeroen Kasichayanula, Sreeneeranj Edwards, Alena Y. van der Graaf, Piet H. Zhang, Lei Wagner, John A. |
author_sort | Ramamoorthy, Anuradha |
collection | PubMed |
description | The consumption of asparagus is associated with the production of malodorous urine with considerable interindividual variability (IIV). To characterize the urinary odor kinetics after consumption of asparagus spears, we conducted a study with consenting attendees from two American Society for Clinical Pharmacology and Therapeutics (ASCPT) meetings. Subjects were randomized to eat a specific number of asparagus spears, and then asked to report their urinary odor perception. Eighty‐seven subjects were included in the final analysis. A mixed effect proportional odds model was developed that adequately characterized the dose‐response relationship. We estimated the half‐life of the asparagus effect on malodorous urine to be 4.7 hours (relative standard error (RSE) = 13.2%), and identified a dose‐response slope term with good precision (24.3%). Age was found as the predictor of IIV in slope estimates. This study design and tools can be used as a demonstration “crowdsourcing” project for studying population kinetics in organizational and educational settings. |
format | Online Article Text |
id | pubmed-5784735 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57847352018-02-07 Crowdsourced Asparagus Urinary Odor Population Kinetics Ramamoorthy, Anuradha Sadler, Brian M. van Hasselt, J.G. Coen Elassaiss‐Schaap, Jeroen Kasichayanula, Sreeneeranj Edwards, Alena Y. van der Graaf, Piet H. Zhang, Lei Wagner, John A. CPT Pharmacometrics Syst Pharmacol Original Articles The consumption of asparagus is associated with the production of malodorous urine with considerable interindividual variability (IIV). To characterize the urinary odor kinetics after consumption of asparagus spears, we conducted a study with consenting attendees from two American Society for Clinical Pharmacology and Therapeutics (ASCPT) meetings. Subjects were randomized to eat a specific number of asparagus spears, and then asked to report their urinary odor perception. Eighty‐seven subjects were included in the final analysis. A mixed effect proportional odds model was developed that adequately characterized the dose‐response relationship. We estimated the half‐life of the asparagus effect on malodorous urine to be 4.7 hours (relative standard error (RSE) = 13.2%), and identified a dose‐response slope term with good precision (24.3%). Age was found as the predictor of IIV in slope estimates. This study design and tools can be used as a demonstration “crowdsourcing” project for studying population kinetics in organizational and educational settings. John Wiley and Sons Inc. 2017-12-14 2018-01 /pmc/articles/PMC5784735/ /pubmed/29239147 http://dx.doi.org/10.1002/psp4.12264 Text en © 2017 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Ramamoorthy, Anuradha Sadler, Brian M. van Hasselt, J.G. Coen Elassaiss‐Schaap, Jeroen Kasichayanula, Sreeneeranj Edwards, Alena Y. van der Graaf, Piet H. Zhang, Lei Wagner, John A. Crowdsourced Asparagus Urinary Odor Population Kinetics |
title | Crowdsourced Asparagus Urinary Odor Population Kinetics |
title_full | Crowdsourced Asparagus Urinary Odor Population Kinetics |
title_fullStr | Crowdsourced Asparagus Urinary Odor Population Kinetics |
title_full_unstemmed | Crowdsourced Asparagus Urinary Odor Population Kinetics |
title_short | Crowdsourced Asparagus Urinary Odor Population Kinetics |
title_sort | crowdsourced asparagus urinary odor population kinetics |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784735/ https://www.ncbi.nlm.nih.gov/pubmed/29239147 http://dx.doi.org/10.1002/psp4.12264 |
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