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Optical coherence tomography angiography in choroidal melanoma and nevus

SYNOPSIS: In optical coherence tomography angiography, the choroidal vascular flow rate in choroidal melanoma is significantly lower than that in choroidal nevus. OBJECTIVE: The objective of this study was to describe the choriocapillaris and retinal features imaged by optical coherence tomography a...

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Autores principales: Ghassemi, Fariba, Mirshahi, Reza, Fadakar, Kaveh, Sabour, Siamak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784746/
https://www.ncbi.nlm.nih.gov/pubmed/29403262
http://dx.doi.org/10.2147/OPTH.S148897
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author Ghassemi, Fariba
Mirshahi, Reza
Fadakar, Kaveh
Sabour, Siamak
author_facet Ghassemi, Fariba
Mirshahi, Reza
Fadakar, Kaveh
Sabour, Siamak
author_sort Ghassemi, Fariba
collection PubMed
description SYNOPSIS: In optical coherence tomography angiography, the choroidal vascular flow rate in choroidal melanoma is significantly lower than that in choroidal nevus. OBJECTIVE: The objective of this study was to describe the choriocapillaris and retinal features imaged by optical coherence tomography angiography (OCTA) in eyes with choroidal nevus from small malignant choroidal melanoma. METHODS: In this retrospective, noninvasive, observational study, 11 patients diagnosed with small choroidal mass (five with choroidal nevus and six with malignant melanoma) who underwent dilated fundus examination, ocular ultrasonography and OCTA images were compared. RESULTS: In choroidal nevus of all patients, OCTA demonstrated a hyporeflective mass with no significant deformity of choroidal vasculature and an intact retinal pigment epithelium (RPE)–Bruch’s membrane complex. The flow void mass was surrounded by an intense vascular rim named as surface microvasculature (SMV) that had an approximately similar flow rate median of 63.68 mm(2) (60.42–67.62 mm(2)), comparable with the median of the contralateral normal eye of 61.77 mm(2) (60.42–64.53 mm(2); P>0.09) for nevi. OCTA showed an obscured Bruch’s membrane–RPE–Bruch’s membrane complex and outer retinal layer in choroidal melanomas. Choriocapillaris flow rate over the melanomas was 55.73% (41.93%–60.82%), and the corresponding normal areas had a flow area of 62.75% (61.99%–63.10%; P=0.01). A flow rate difference between choroidal melanoma and nevus was significant (P=0.006). Axial and peripheral feeding vessels were more dilated and tortuous compared with benign nevi. CONCLUSION: Decreased flow rate of SMV of choroidal melanoma cases compared with nevi was a significant finding. Detection of characteristic vascular features of choroidal melanoma by OCTA could make OCTA an assuring diagnostic modality to differentiate malignant lesions.
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spelling pubmed-57847462018-02-05 Optical coherence tomography angiography in choroidal melanoma and nevus Ghassemi, Fariba Mirshahi, Reza Fadakar, Kaveh Sabour, Siamak Clin Ophthalmol Original Research SYNOPSIS: In optical coherence tomography angiography, the choroidal vascular flow rate in choroidal melanoma is significantly lower than that in choroidal nevus. OBJECTIVE: The objective of this study was to describe the choriocapillaris and retinal features imaged by optical coherence tomography angiography (OCTA) in eyes with choroidal nevus from small malignant choroidal melanoma. METHODS: In this retrospective, noninvasive, observational study, 11 patients diagnosed with small choroidal mass (five with choroidal nevus and six with malignant melanoma) who underwent dilated fundus examination, ocular ultrasonography and OCTA images were compared. RESULTS: In choroidal nevus of all patients, OCTA demonstrated a hyporeflective mass with no significant deformity of choroidal vasculature and an intact retinal pigment epithelium (RPE)–Bruch’s membrane complex. The flow void mass was surrounded by an intense vascular rim named as surface microvasculature (SMV) that had an approximately similar flow rate median of 63.68 mm(2) (60.42–67.62 mm(2)), comparable with the median of the contralateral normal eye of 61.77 mm(2) (60.42–64.53 mm(2); P>0.09) for nevi. OCTA showed an obscured Bruch’s membrane–RPE–Bruch’s membrane complex and outer retinal layer in choroidal melanomas. Choriocapillaris flow rate over the melanomas was 55.73% (41.93%–60.82%), and the corresponding normal areas had a flow area of 62.75% (61.99%–63.10%; P=0.01). A flow rate difference between choroidal melanoma and nevus was significant (P=0.006). Axial and peripheral feeding vessels were more dilated and tortuous compared with benign nevi. CONCLUSION: Decreased flow rate of SMV of choroidal melanoma cases compared with nevi was a significant finding. Detection of characteristic vascular features of choroidal melanoma by OCTA could make OCTA an assuring diagnostic modality to differentiate malignant lesions. Dove Medical Press 2018-01-22 /pmc/articles/PMC5784746/ /pubmed/29403262 http://dx.doi.org/10.2147/OPTH.S148897 Text en © 2018 Ghassemi et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Ghassemi, Fariba
Mirshahi, Reza
Fadakar, Kaveh
Sabour, Siamak
Optical coherence tomography angiography in choroidal melanoma and nevus
title Optical coherence tomography angiography in choroidal melanoma and nevus
title_full Optical coherence tomography angiography in choroidal melanoma and nevus
title_fullStr Optical coherence tomography angiography in choroidal melanoma and nevus
title_full_unstemmed Optical coherence tomography angiography in choroidal melanoma and nevus
title_short Optical coherence tomography angiography in choroidal melanoma and nevus
title_sort optical coherence tomography angiography in choroidal melanoma and nevus
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784746/
https://www.ncbi.nlm.nih.gov/pubmed/29403262
http://dx.doi.org/10.2147/OPTH.S148897
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