Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study

BACKGROUND: The metabolic basis of Alzheimer disease (AD) is poorly understood, and the relationships between systemic abnormalities in metabolism and AD pathogenesis are unclear. Understanding how global perturbations in metabolism are related to severity of AD neuropathology and the eventual expre...

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Detalles Bibliográficos
Autores principales: Varma, Vijay R., Oommen, Anup M., Varma, Sudhir, Casanova, Ramon, An, Yang, Andrews, Ryan M., O’Brien, Richard, Pletnikova, Olga, Troncoso, Juan C., Toledo, Jon, Baillie, Rebecca, Arnold, Matthias, Kastenmueller, Gabi, Nho, Kwangsik, Doraiswamy, P. Murali, Saykin, Andrew J., Kaddurah-Daouk, Rima, Legido-Quigley, Cristina, Thambisetty, Madhav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784884/
https://www.ncbi.nlm.nih.gov/pubmed/29370177
http://dx.doi.org/10.1371/journal.pmed.1002482

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