Taking cohesin and condensin in context

Structural maintenance of chromosome (SMC) protein complexes, including cohesin and condensin, are increasingly being recognized for their important role in cancer and development, making it critical that we understand how these evolutionarily conserved multi-subunit protein complexes associate with...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuen, Kobe C., Gerton, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784890/
https://www.ncbi.nlm.nih.gov/pubmed/29370184
http://dx.doi.org/10.1371/journal.pgen.1007118
_version_ 1783295527607074816
author Yuen, Kobe C.
Gerton, Jennifer L.
author_facet Yuen, Kobe C.
Gerton, Jennifer L.
author_sort Yuen, Kobe C.
collection PubMed
description Structural maintenance of chromosome (SMC) protein complexes, including cohesin and condensin, are increasingly being recognized for their important role in cancer and development, making it critical that we understand how these evolutionarily conserved multi-subunit protein complexes associate with and organize the genome. We review adaptor proteins for SMC complexes and how these adaptors may capture SMC complexes following loop extrusion to provide a framework for chromosome organization.
format Online
Article
Text
id pubmed-5784890
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-57848902018-02-09 Taking cohesin and condensin in context Yuen, Kobe C. Gerton, Jennifer L. PLoS Genet Review Structural maintenance of chromosome (SMC) protein complexes, including cohesin and condensin, are increasingly being recognized for their important role in cancer and development, making it critical that we understand how these evolutionarily conserved multi-subunit protein complexes associate with and organize the genome. We review adaptor proteins for SMC complexes and how these adaptors may capture SMC complexes following loop extrusion to provide a framework for chromosome organization. Public Library of Science 2018-01-25 /pmc/articles/PMC5784890/ /pubmed/29370184 http://dx.doi.org/10.1371/journal.pgen.1007118 Text en © 2018 Yuen, Gerton http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Yuen, Kobe C.
Gerton, Jennifer L.
Taking cohesin and condensin in context
title Taking cohesin and condensin in context
title_full Taking cohesin and condensin in context
title_fullStr Taking cohesin and condensin in context
title_full_unstemmed Taking cohesin and condensin in context
title_short Taking cohesin and condensin in context
title_sort taking cohesin and condensin in context
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784890/
https://www.ncbi.nlm.nih.gov/pubmed/29370184
http://dx.doi.org/10.1371/journal.pgen.1007118
work_keys_str_mv AT yuenkobec takingcohesinandcondensinincontext
AT gertonjenniferl takingcohesinandcondensinincontext

Ejemplares similares