+mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain

LRRC55 (leucine-rich repeat-containing protein 55) protein is an auxiliary γ subunit of BK (Big conductance potassium channel) channels, which leftward shifts GVs of BK channels around 50 mV in the absence of cytosolic Ca(2+). LRRC55 protein is also the only γ subunit of BK channels that is expresse...

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Detalles Bibliográficos
Autores principales: Zhang, Ying-Ying, Han, Xue, Liu, Ye, Chen, Jian, Hua, Lei, Ma, Qian, Huang, Yang-Yu-Xin, Tang, Qiong-Yao, Zhang, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784982/
https://www.ncbi.nlm.nih.gov/pubmed/29370300
http://dx.doi.org/10.1371/journal.pone.0191749
Descripción
Sumario:LRRC55 (leucine-rich repeat-containing protein 55) protein is an auxiliary γ subunit of BK (Big conductance potassium channel) channels, which leftward shifts GVs of BK channels around 50 mV in the absence of cytosolic Ca(2+). LRRC55 protein is also the only γ subunit of BK channels that is expressed in mammalian nervous system. However, the expression pattern of LRRC55 gene in adult mammalian brain remains elusive. In this study, we investigated the distribution of LRRC55 mRNA in the adult mouse brain by using in situ hybridization. We found that LRRC55 mRNA is richly expressed in the adult mouse medial habenula nucleus (MHb), cerebellum and pons. However, the potential role of LRRC55 in MHb and cerebellum could be different based on the function of BK channels in these brain regions.

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