+mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain

LRRC55 (leucine-rich repeat-containing protein 55) protein is an auxiliary γ subunit of BK (Big conductance potassium channel) channels, which leftward shifts GVs of BK channels around 50 mV in the absence of cytosolic Ca(2+). LRRC55 protein is also the only γ subunit of BK channels that is expresse...

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Autores principales: Zhang, Ying-Ying, Han, Xue, Liu, Ye, Chen, Jian, Hua, Lei, Ma, Qian, Huang, Yang-Yu-Xin, Tang, Qiong-Yao, Zhang, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784982/
https://www.ncbi.nlm.nih.gov/pubmed/29370300
http://dx.doi.org/10.1371/journal.pone.0191749
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author Zhang, Ying-Ying
Han, Xue
Liu, Ye
Chen, Jian
Hua, Lei
Ma, Qian
Huang, Yang-Yu-Xin
Tang, Qiong-Yao
Zhang, Zhe
author_facet Zhang, Ying-Ying
Han, Xue
Liu, Ye
Chen, Jian
Hua, Lei
Ma, Qian
Huang, Yang-Yu-Xin
Tang, Qiong-Yao
Zhang, Zhe
author_sort Zhang, Ying-Ying
collection PubMed
description LRRC55 (leucine-rich repeat-containing protein 55) protein is an auxiliary γ subunit of BK (Big conductance potassium channel) channels, which leftward shifts GVs of BK channels around 50 mV in the absence of cytosolic Ca(2+). LRRC55 protein is also the only γ subunit of BK channels that is expressed in mammalian nervous system. However, the expression pattern of LRRC55 gene in adult mammalian brain remains elusive. In this study, we investigated the distribution of LRRC55 mRNA in the adult mouse brain by using in situ hybridization. We found that LRRC55 mRNA is richly expressed in the adult mouse medial habenula nucleus (MHb), cerebellum and pons. However, the potential role of LRRC55 in MHb and cerebellum could be different based on the function of BK channels in these brain regions.
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spelling pubmed-57849822018-02-09 +mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain Zhang, Ying-Ying Han, Xue Liu, Ye Chen, Jian Hua, Lei Ma, Qian Huang, Yang-Yu-Xin Tang, Qiong-Yao Zhang, Zhe PLoS One Research Article LRRC55 (leucine-rich repeat-containing protein 55) protein is an auxiliary γ subunit of BK (Big conductance potassium channel) channels, which leftward shifts GVs of BK channels around 50 mV in the absence of cytosolic Ca(2+). LRRC55 protein is also the only γ subunit of BK channels that is expressed in mammalian nervous system. However, the expression pattern of LRRC55 gene in adult mammalian brain remains elusive. In this study, we investigated the distribution of LRRC55 mRNA in the adult mouse brain by using in situ hybridization. We found that LRRC55 mRNA is richly expressed in the adult mouse medial habenula nucleus (MHb), cerebellum and pons. However, the potential role of LRRC55 in MHb and cerebellum could be different based on the function of BK channels in these brain regions. Public Library of Science 2018-01-25 /pmc/articles/PMC5784982/ /pubmed/29370300 http://dx.doi.org/10.1371/journal.pone.0191749 Text en © 2018 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zhang, Ying-Ying
Han, Xue
Liu, Ye
Chen, Jian
Hua, Lei
Ma, Qian
Huang, Yang-Yu-Xin
Tang, Qiong-Yao
Zhang, Zhe
+mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain
title +mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain
title_full +mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain
title_fullStr +mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain
title_full_unstemmed +mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain
title_short +mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain
title_sort +mrna expression of lrrc55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784982/
https://www.ncbi.nlm.nih.gov/pubmed/29370300
http://dx.doi.org/10.1371/journal.pone.0191749
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