The reliability of molecular dynamics simulations of the multidrug transporter P-glycoprotein in a membrane environment

Despite decades of research, the mechanism of action of the ABC multidrug transporter P-glycoprotein (P-gp) remains elusive. Due to experimental limitations, many researchers have turned to molecular dynamics simulation studies in order to investigate different aspects of P-gp function. However, suc...

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Detalles Bibliográficos
Autores principales: Condic-Jurkic, Karmen, Subramanian, Nandhitha, Mark, Alan E., O’Mara, Megan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785007/
https://www.ncbi.nlm.nih.gov/pubmed/29370310
http://dx.doi.org/10.1371/journal.pone.0191882

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