Influence of the loop size and nucleotide composition on AgoshRNA biogenesis and activity

Short hairpin RNAs (shRNAs) are widely used for gene silencing by the RNA interference (RNAi) mechanism. The shRNA precursor is processed by the Dicer enzyme into active small interfering RNAs (siRNAs) that subsequently target a complementary mRNA for cleavage by the Argonaute 2 (Ago2) complex. Rece...

Descripción completa

Detalles Bibliográficos
Autores principales: Herrera-Carrillo, Elena, Harwig, Alex, Berkhout, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785215/
https://www.ncbi.nlm.nih.gov/pubmed/28569591
http://dx.doi.org/10.1080/15476286.2017.1328349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785215/
https://www.ncbi.nlm.nih.gov/pubmed/28569591
http://dx.doi.org/10.1080/15476286.2017.1328349

Ejemplares similares