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The PAF Complex Regulation of Prmt5 Facilitates the Progression and Maintenance of MLL-Fusion Leukemia

Acute myeloid leukemia (AML) is a disease associated with epigenetic dysregulation. 11q23 translocations involving the H3K4 methyltransferase MLL1 (KMT2A) generate oncogenic fusion proteins with deregulated transcriptional potential. The Polymerase Associated Factor complex (PAFc) is an epigenetic c...

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Detalles Bibliográficos
Autores principales:	Serio, Justin, Ropa, James, Chen, Wei, Mysliwski, Maria, Saha, Nirmalya, Chen, Lili, Wang, Jingya, Miao, Hongzhi, Cierpicki, Tomasz, Grembecka, Jolanta, Muntean, Andrew G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785415/ https://www.ncbi.nlm.nih.gov/pubmed/28945229 http://dx.doi.org/10.1038/onc.2017.337

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