Defective positioning in granulomas but not lung-homing limits CD4 T cell interactions with Mycobacterium tuberculosis infected macrophages in rhesus macaques

Protection against Mycobacterium tuberculosis (Mtb) infection requires CD4 T cells to migrate into the lung and interact with infected macrophages. In mice, less-differentiated CXCR3(+) CD4 T cells migrate into the lung and suppress growth of Mtb, while CX3CR1(+) terminally-differentiated Th1 cells...

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Detalles Bibliográficos
Autores principales: Kauffman, Keith D., Sallin, Michelle A., Sakai, Shunsuke, Kamenyeva, Olena, Kabat, Juraj, Weiner, Danielle, Sutphin, Michelle, Schimel, Daniel, Via, Laura, Barry, Clifton E., Wilder-Kofie, Temeri, Moore, Ian, Moore, Rashida, Barber, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785573/
https://www.ncbi.nlm.nih.gov/pubmed/28745326
http://dx.doi.org/10.1038/mi.2017.60

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