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Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?

OBJECTIVE: Metabolic impairment in type 1 diabetes mellitus (T1DM) with poor glycemic control causes insulin resistance, non-alcoholic fatty liver disease (NAFLD), atherosclerosis, and increased carotid intima-media thickness (CIMT). Fetuin-A has a protective effect in cardiovascular disorders and i...

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Autores principales: Şiraz, Ülkü Gül, Doğan, Murat, Hatipoğlu, Nihal, Muhtaroğlu, Sabahattin, Kurtoğlu, Selim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785634/
https://www.ncbi.nlm.nih.gov/pubmed/28529199
http://dx.doi.org/10.4274/jcrpe.4532
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author Şiraz, Ülkü Gül
Doğan, Murat
Hatipoğlu, Nihal
Muhtaroğlu, Sabahattin
Kurtoğlu, Selim
author_facet Şiraz, Ülkü Gül
Doğan, Murat
Hatipoğlu, Nihal
Muhtaroğlu, Sabahattin
Kurtoğlu, Selim
author_sort Şiraz, Ülkü Gül
collection PubMed
description OBJECTIVE: Metabolic impairment in type 1 diabetes mellitus (T1DM) with poor glycemic control causes insulin resistance, non-alcoholic fatty liver disease (NAFLD), atherosclerosis, and increased carotid intima-media thickness (CIMT). Fetuin-A has a protective effect in cardiovascular disorders and is increased in hepatosteatosis. We aimed to investigate the reliability of fetuin-A levels in early detection of diabetic complications in children with T1DM and to identify a cut-off value that may show poor metabolic control. METHODS: The study included 80 patients who had T1DM for at least 5 years and who had no chronic complications or an auto-immune disorder. Blood samples were drawn to measure hemoglobin A1c (HbA1c), biochemical parameters, and fetuin-A levels. Anthropometric parameters were also measured. Percent body fat was calculated. Hepatosteatosis and CIMT were assessed by sonography. RESULTS: Mean age of the patients was 13.5 years. Grade 1 hepatosteatosis was detected in 10%. Patients were stratified into 2 groups based on presence of NAFLD. Fetuin-A level was increased in patients with NAFLD. We identified a fetuin-A cut-off value (514.28 ng/mL; sensitivity: 47.34; specificity: 96.72) that may predict NAFLD. HbA1c and total cholesterol levels were found to be higher in patients with fetuin-A levels above higher the cut-off value. CONCLUSION: Fetuin-A is a reliable parameter in the prediction of complications and poor glycemic control in patients with T1DM.
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spelling pubmed-57856342018-01-30 Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus? Şiraz, Ülkü Gül Doğan, Murat Hatipoğlu, Nihal Muhtaroğlu, Sabahattin Kurtoğlu, Selim J Clin Res Pediatr Endocrinol Original Article OBJECTIVE: Metabolic impairment in type 1 diabetes mellitus (T1DM) with poor glycemic control causes insulin resistance, non-alcoholic fatty liver disease (NAFLD), atherosclerosis, and increased carotid intima-media thickness (CIMT). Fetuin-A has a protective effect in cardiovascular disorders and is increased in hepatosteatosis. We aimed to investigate the reliability of fetuin-A levels in early detection of diabetic complications in children with T1DM and to identify a cut-off value that may show poor metabolic control. METHODS: The study included 80 patients who had T1DM for at least 5 years and who had no chronic complications or an auto-immune disorder. Blood samples were drawn to measure hemoglobin A1c (HbA1c), biochemical parameters, and fetuin-A levels. Anthropometric parameters were also measured. Percent body fat was calculated. Hepatosteatosis and CIMT were assessed by sonography. RESULTS: Mean age of the patients was 13.5 years. Grade 1 hepatosteatosis was detected in 10%. Patients were stratified into 2 groups based on presence of NAFLD. Fetuin-A level was increased in patients with NAFLD. We identified a fetuin-A cut-off value (514.28 ng/mL; sensitivity: 47.34; specificity: 96.72) that may predict NAFLD. HbA1c and total cholesterol levels were found to be higher in patients with fetuin-A levels above higher the cut-off value. CONCLUSION: Fetuin-A is a reliable parameter in the prediction of complications and poor glycemic control in patients with T1DM. Galenos Publishing 2017-12 2017-12-15 /pmc/articles/PMC5785634/ /pubmed/28529199 http://dx.doi.org/10.4274/jcrpe.4532 Text en ©Copyright 2017 by Turkish Pediatric Endocrinology and Diabetes Society The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Şiraz, Ülkü Gül
Doğan, Murat
Hatipoğlu, Nihal
Muhtaroğlu, Sabahattin
Kurtoğlu, Selim
Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?
title Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?
title_full Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?
title_fullStr Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?
title_full_unstemmed Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?
title_short Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?
title_sort can fetuin-a be a marker for insulin resistance and poor glycemic control in children with type 1 diabetes mellitus?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785634/
https://www.ncbi.nlm.nih.gov/pubmed/28529199
http://dx.doi.org/10.4274/jcrpe.4532
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