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Decreased Sirtuin Deacetylase Activity in LRRK2 G2019S iPSC-Derived Dopaminergic Neurons

Mitochondrial changes have long been implicated in the pathogenesis of Parkinson's disease (PD). The glycine to serine mutation (G2019S) in leucine-rich repeat kinase 2 (LRRK2) is the most common genetic cause for PD and has been shown to impair mitochondrial function and morphology in multiple...

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Detalles Bibliográficos
Autores principales:	Schwab, Andrew J., Sison, Samantha L., Meade, Michael R., Broniowska, Katarzyna A., Corbett, John A., Ebert, Allison D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785678/ https://www.ncbi.nlm.nih.gov/pubmed/29129681 http://dx.doi.org/10.1016/j.stemcr.2017.10.010

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