Cargando…

The effectiveness and safety of anti-fibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis

Abstract Introduction: The Anti-fibrinolytics Trialists Collaboration aims to increase knowledge about the effectiveness and safety of anti-fibrinolytic treatment by conducting individual patient data (IPD) meta-analyses of randomised trials. This article presents the statistical analysis plan for a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ker, Katharine, Prieto-Merino, David, Sprigg, Nikola, Mahmood, Abda, Bath, Philip, Kang Law, Zhe, Flaherty, Katie, Roberts, Ian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	F1000 Research Limited 2019
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785711/ https://www.ncbi.nlm.nih.gov/pubmed/29417096 http://dx.doi.org/10.12688/wellcomeopenres.13262.3

Ejemplares similares

Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial
por: Flaherty, Katie, et al.
Publicado: (2017)

Prevention of haematoma progression by tranexamic acid in intracerebral haemorrhage patients with and without spot sign on admission scan: a statistical analysis plan of a pre-specified sub-study of the TICH-2 trial
por: Ovesen, Christian, et al.
Publicado: (2018)

A nested randomised trial of the effect of tranexamic acid on intracranial haemorrhage and infarction in traumatic brain injury (CRASH-3 trial intracranial bleeding mechanistic study): Statistical analysis plan
por: Mahmood, Abda, et al.
Publicado: (2019)

Measures of intracranial compartments in acute intracerebral haemorrhage: data from the Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke-2 Trial (RIGHT-2)
por: Krishnan, Kailash, et al.
Publicado: (2022)

Does tranexamic acid lead to changes in MRI measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? Protocol for a MRI substudy nested within the double-blind randomised controlled TICH-2 trial
por: Dineen, Rob A, et al.
Publicado: (2018)

Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients
por: Gayet-Ageron, Angèle, et al.
Publicado: (2018)

Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms
por: Roberts, Ian, et al.
Publicado: (2017)

Automated segmentation of haematoma and perihaematomal oedema in MRI of acute spontaneous intracerebral haemorrhage
por: Pszczolkowski, Stefan, et al.
Publicado: (2019)

Quantitative CT radiomics-based models for prediction of haematoma expansion and poor functional outcome in primary intracerebral haemorrhage
por: Pszczolkowski, Stefan, et al.
Publicado: (2021)

Intracranial Bleeding After Reperfusion Therapy in Acute Ischaemic Stroke Patients Randomized to Glyceryl Trinitrate vs. Control: An Individual Patient Data Meta-Analysis
por: Appleton, Jason P., et al.
Publicado: (2020)

A nested mechanistic sub-study into the effect of tranexamic acid versus placebo on intracranial haemorrhage and cerebral ischaemia in isolated traumatic brain injury: study protocol for a randomised controlled trial (CRASH-3 Trial Intracranial Bleeding Mechanistic Sub-Study [CRASH-3 IBMS])
por: Mahmood, Abda, et al.
Publicado: (2017)

Haematological and fibrinolytic status of Nigerian women with post-partum haemorrhage
por: Roberts, Ian, et al.
Publicado: (2018)

Corrigendum: Intracranial Bleeding After Reperfusion Therapy in Acute Ischaemic Stroke Patients Randomized to Glyceryl Trinitrate vs. Control: An Individual Patient Data Meta-Analysis
por: Appleton, Jason P., et al.
Publicado: (2020)

Anti-fibrinolytic agents in post partum haemorrhage: a systematic review
por: Ferrer, Pili, et al.
Publicado: (2009)

Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial
por: Appleton, Jason P., et al.
Publicado: (2019)

Statistical analysis plan for the ‘Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke’ (TARDIS) trial
por: Bath, Philip M W, et al.
Publicado: (2015)

Tranexamic acid for post-partum haemorrhage: What, who and when
por: Brenner, Amy, et al.
Publicado: (2019)

Statistical analysis plan for the ‘Efficacy of Nitric Oxide in Stroke’ (ENOS) trial
por: Bath, Philip M W, et al.
Publicado: (2014)

Early lowering of blood pressure after acute intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data
por: Moullaali, Tom J, et al.
Publicado: (2022)

Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood Pressure in Acute Stroke Collaboration (BASC)
por: Moullaali, Tom J, et al.
Publicado: (2019)

Effects of blood pressure and tranexamic acid in spontaneous intracerebral haemorrhage: a secondary analysis of a large randomised controlled trial
por: Appleton, Jason Philip, et al.
Publicado: (2023)

Effect of tranexamic acid on intracranial haemorrhage and infarction in patients with traumatic brain injury: a pre-planned substudy in a sample of CRASH-3 trial patients
por: Mahmood, Abda, et al.
Publicado: (2021)

Intracranial pressure monitoring in patients with subarachnoid haemorrhage
por: Cormio, M, et al.
Publicado: (2001)

Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial
por: Sprigg, Nikola, et al.
Publicado: (2018)

Outcome measures in clinical trials of treatments for acute severe haemorrhage
por: Brenner, Amy, et al.
Publicado: (2018)

Desmopressin Acetate in Intracranial Haemorrhage
por: Kapapa, Thomas, et al.
Publicado: (2014)

Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: The LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial
por: Blair, Gordon W., et al.
Publicado: (2019)

Granulocyte-Colony Stimulating Factor (G-CSF) for stroke: an individual patient data meta-analysis
por: England, Timothy J., et al.
Publicado: (2016)

Fibrinolytic System and Cancer: Diagnostic and Therapeutic Applications
por: Mahmood, Niaz, et al.
Publicado: (2021)

Remote Assessment of Platelet Function in Patients with Acute Stroke or Transient Ischaemic Attack
por: Bath, Philip M., et al.
Publicado: (2017)

Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke
por: Rakkar, Kamini, et al.
Publicado: (2023)

A clinical characteristic analysis of pregnancy-associated intracranial haemorrhage in China
por: Liang, Zhu-Wei, et al.
Publicado: (2015)

Efficacy and safety of tranexamic acid in intracranial haemorrhage: A meta-analysis
por: Xiong, Yu, et al.
Publicado: (2023)

Therapeutic Potential of Transdermal Glyceryl Trinitrate in the Management of Acute Stroke
por: Appleton, Jason P., et al.
Publicado: (2016)

Blood pressure management in acute stroke
por: Appleton, Jason P, et al.
Publicado: (2016)

Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy: international individual patient data pooled analysis
por: Hostettler, Isabel Charlotte, et al.
Publicado: (2021)

Intracranial haemorrhage in dural arteriovenous fistula
por: Garg, Tushar
Publicado: (2019)

A case of hemothorax secondary to intrapleural fibrinolytic therapy: Considerations for use of fibrinolytics in high-risk patients
por: Narula, Naureen, et al.
Publicado: (2021)

Retrospective analysis and prospective validation of an AI-based software for intracranial haemorrhage detection at a high-volume trauma centre
por: Zia, Adil, et al.
Publicado: (2022)

The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: statistical analysis plan for a randomised controlled trial
por: Al-Shahi Salman, Rustam, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0ersnh0sq1s4fhu9f2125uhcam