Altered Differentiation Potential of Gaucher’s Disease iPSC Neuronal Progenitors due to Wnt/β-Catenin Downregulation

Gaucher’s disease (GD) is an autosomal recessive disorder caused by mutations in the GBA1 gene, which encodes acid β-glucocerebrosidase (GCase). Severe GBA1 mutations cause neuropathology that manifests soon after birth, suggesting that GCase deficiency interferes with neuronal development. We found...

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Detalles Bibliográficos
Autores principales: Awad, Ola, Panicker, Leelamma M., Deranieh, Rania M., Srikanth, Manasa P., Brown, Robert A., Voit, Antanina, Peesay, Tejasvi, Park, Tea Soon, Zambidis, Elias T., Feldman, Ricardo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785733/
https://www.ncbi.nlm.nih.gov/pubmed/29198828
http://dx.doi.org/10.1016/j.stemcr.2017.10.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785733/
https://www.ncbi.nlm.nih.gov/pubmed/29198828
http://dx.doi.org/10.1016/j.stemcr.2017.10.029

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