Phospholipase D inhibitors reduce human prostate cancer cell proliferation and colony formation

BACKGROUND: Phospholipases D1 and D2 (PLD1/2) hydrolyse cell membrane glycerophospholipids to generate phosphatidic acid, a signalling lipid, which regulates cell growth and cancer progression through effects on mTOR and PKB/Akt. PLD expression and/or activity is raised in breast, colorectal, gastri...

Descripción completa

Detalles Bibliográficos
Autores principales: Noble, Amanda R, Maitland, Norman J, Berney, Daniel M, Rumsby, Martin G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785744/
https://www.ncbi.nlm.nih.gov/pubmed/29136407
http://dx.doi.org/10.1038/bjc.2017.391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785744/
https://www.ncbi.nlm.nih.gov/pubmed/29136407
http://dx.doi.org/10.1038/bjc.2017.391

Ejemplares similares