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Phospholipase D inhibitors reduce human prostate cancer cell proliferation and colony formation
BACKGROUND: Phospholipases D1 and D2 (PLD1/2) hydrolyse cell membrane glycerophospholipids to generate phosphatidic acid, a signalling lipid, which regulates cell growth and cancer progression through effects on mTOR and PKB/Akt. PLD expression and/or activity is raised in breast, colorectal, gastri...
Autores principales: | Noble, Amanda R, Maitland, Norman J, Berney, Daniel M, Rumsby, Martin G |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785744/ https://www.ncbi.nlm.nih.gov/pubmed/29136407 http://dx.doi.org/10.1038/bjc.2017.391 |
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