Cargando…

REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment

[Image: see text] Bryostatin 1 (henceforth bryostatin) is in clinical trials for the treatment of Alzheimer’s disease and for HIV/AIDS eradication. It is also a preclinical lead for cancer immunotherapy and other therapeutic indications. Yet nothing is known about the conformation of bryostatin boun...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Hao, Staveness, Daryl, Ryckbosch, Steven M., Axtman, Alison D., Loy, Brian A., Barnes, Alexander B., Pande, Vijay S., Schaefer, Jacob, Wender, Paul A., Cegelski, Lynette
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785774/ https://www.ncbi.nlm.nih.gov/pubmed/29392180 http://dx.doi.org/10.1021/acscentsci.7b00475

Ejemplares similares

The Application of REDOR NMR to Understand the Conformation of Epothilone B
por: Lee, Jae-Ho, et al.
Publicado: (2017)

Improved Protein Kinase C Affinity through Final Step Diversification of a Simplified Salicylate-Derived Bryostatin Analog Scaffold
por: Wender, Paul A., et al.
Publicado: (2014)

Monitoring tat peptide binding to TAR RNA by solid-state (31)P–(19)F REDOR NMR
por: Olsen, Greg L., et al.
Publicado: (2005)

Three Decades of REDOR in Protein Science: A Solid-State NMR Technique for Distance Measurement and Spectral Editing
por: Toke, Orsolya
Publicado: (2023)

Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes
por: Ryckbosch, Steven M., et al.
Publicado: (2017)

Computer-Guided Design, Synthesis, and Protein Kinase C Affinity of a New Salicylate-Based Class of Bryostatin Analogs
por: Wender, Paul A., et al.
Publicado: (2014)

Une association s'installe à Genève pour redorer le blason de la science
por: Deruaz, A
Publicado: (1997)

Quantification of free ligand conformational preferences by NMR and their relationship to the bioactive conformation()
por: Blundell, Charles D., et al.
Publicado: (2013)

Ligand-driven conformational changes of MurD visualized by paramagnetic NMR
por: Saio, Tomohide, et al.
Publicado: (2015)

The Congo red derivative FSB binds to curli amyloid fibers and specifically stains curliated E. coli
por: Reichhardt, Courtney, et al.
Publicado: (2018)

Catching Threads in Bacterial Cell Walls
por: Kallem, Till, et al.
Publicado: (2022)

Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death
por: Staveness, Daryl, et al.
Publicado: (2016)

In Vivo Targeting of Escherichia coli with Vancomycin-Arginine
por: Neville, Lewis F., et al.
Publicado: (2021)

Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors
por: Wender, Paul A., et al.
Publicado: (2014)

Conformational Dynamics of a Ligand-Free Adenylate Kinase
por: Song, Hyun Deok, et al.
Publicado: (2013)

Millisecond dynamics of BTK reveal kinome-wide conformational plasticity within the apo kinase domain
por: Sultan, Mohammad M., et al.
Publicado: (2017)

Unraveling Escherichia coli’s Cloak: Identification of Phosphoethanolamine Cellulose, Its Functions, and Applications
por: Jeffries, Jamie, et al.
Publicado: (2019)

Free Radical Chemistry Enabled by Visible Light-Induced Electron Transfer
por: Staveness, Daryl, et al.
Publicado: (2016)

A Selective NMR Probe to Monitor the Conformational Transition from Inactive to Active Kinase
por: Xie, Qian, et al.
Publicado: (2014)

Conformational heterogeneity of the calmodulin binding interface
por: Shukla, Diwakar, et al.
Publicado: (2016)

Corrigendum: Conformational heterogeneity of the calmodulin binding interface
por: Shukla, Diwakar, et al.
Publicado: (2016)

Conformations and Physicochemical Properties of Biological Ligands in Various Environments
por: Le Questel, Jean-Yves
Publicado: (2023)

Conformational plasticity of ligand-bound and ternary GPCR complexes studied by (19)F NMR of the β(1)-adrenergic receptor
por: Frei, J. Niclas, et al.
Publicado: (2020)

Complex peptide macrocycle optimization: combining NMR restraints with conformational analysis to guide structure-based and ligand-based design
por: Jain, Ajay N., et al.
Publicado: (2023)

Persistent Topology and Metastable State in Conformational Dynamics
por: Chang, Huang-Wei, et al.
Publicado: (2013)

Novel NMR Avenues to Explore the Conformation and Interactions of Glycans
por: Valverde, Pablo, et al.
Publicado: (2019)

Cloud computing approaches for prediction of ligand binding poses and pathways
por: Lawrenz, Morgan, et al.
Publicado: (2015)

Detection of Ligand‐induced Conformational Changes in the Activation Loop of Aurora‐A Kinase by PELDOR Spectroscopy
por: Burgess, Selena G., et al.
Publicado: (2016)

Conformation of the Macrocyclic Drug Lorlatinib in Polar and Nonpolar Environments: A MD Simulation and NMR Study
por: Peng, Cheng, et al.
Publicado: (2019)

The Dynamic Conformational Cycle of the Group I Chaperonin C-Termini Revealed via Molecular Dynamics Simulation
por: Dalton, Kevin M., et al.
Publicado: (2015)

PI by NMR: Probing CH–π Interactions in Protein–Ligand Complexes by NMR Spectroscopy
por: Platzer, Gerald, et al.
Publicado: (2020)

NMR studies of anion-induced conformational changes in diindolylureas and diindolylthioureas
por: Makuc, Damjan, et al.
Publicado: (2011)

Study of a Conformational Equilibrium of Lisinopril by HPLC, NMR, and DFT
por: Bouabdallah, Sondes, et al.
Publicado: (2014)

Computational and NMR spectroscopy insights into the conformation of cyclic di-nucleotides
por: Wang, Baifan, et al.
Publicado: (2017)

Theoretical and NMR-based Conformational Analysis of Phosphodiester-linked Disaccharides
por: Gerbst, Alexey G., et al.
Publicado: (2017)

Hydrocarbon Macrocycle Conformer Ensembles and (13)C‐NMR Spectra
por: Bohle, Fabian, et al.
Publicado: (2022)

Conformational readout of RNA by small ligands
por: Kligun, Efrat, et al.
Publicado: (2013)

DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl (1)H-NMR probe
por: Liu, Qi, et al.
Publicado: (2020)

Ligand discrimination between active and inactive activation loop conformations of Aurora-A kinase is unmodified by phosphorylation
por: Gilburt, James A. H., et al.
Publicado: (2019)

Characterization of the Raf Kinase Inhibitory Protein (RKIP) Binding Pocket: NMR-Based Screening Identifies Small-Molecule Ligands
por: Shemon, Anne N., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_9cecdibt6d0341i8jd6c8tet7k