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mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway

Control of gene expression is crucial for parasite survival and is the result of a series of processes that are regulated to permit fine-tuning of gene expression in response to biological changes during the life-cycle of apicomplexan parasites. Control of mRNA nuclear export is a key process in euk...

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Autores principales: Ávila, Andréa Rodrigues, Cabezas-Cruz, Alexjandro, Gissot, Mathieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785795/
https://www.ncbi.nlm.nih.gov/pubmed/29370868
http://dx.doi.org/10.1186/s13071-018-2648-4
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author Ávila, Andréa Rodrigues
Cabezas-Cruz, Alexjandro
Gissot, Mathieu
author_facet Ávila, Andréa Rodrigues
Cabezas-Cruz, Alexjandro
Gissot, Mathieu
author_sort Ávila, Andréa Rodrigues
collection PubMed
description Control of gene expression is crucial for parasite survival and is the result of a series of processes that are regulated to permit fine-tuning of gene expression in response to biological changes during the life-cycle of apicomplexan parasites. Control of mRNA nuclear export is a key process in eukaryotic cells but is poorly understood in apicomplexan parasites. Here, we review recent knowledge regarding this process with an emphasis on T. gondii. We describe the presence of divergent orthologs and discuss structural and functional differences in export factors between apicomplexans and other eukaryotic lineages. Undoubtedly, the use of the CRISPR/Cas9 system in high throughput screenings associated with the discovery of mRNA nuclear export complexes by proteomic analysis will contribute to identify these divergent factors. Ligand-based or structure-based strategies may be applied to investigate the potential use of these proteins as targets for new antiprotozoal agents. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13071-018-2648-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-57857952018-02-07 mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway Ávila, Andréa Rodrigues Cabezas-Cruz, Alexjandro Gissot, Mathieu Parasit Vectors Review Control of gene expression is crucial for parasite survival and is the result of a series of processes that are regulated to permit fine-tuning of gene expression in response to biological changes during the life-cycle of apicomplexan parasites. Control of mRNA nuclear export is a key process in eukaryotic cells but is poorly understood in apicomplexan parasites. Here, we review recent knowledge regarding this process with an emphasis on T. gondii. We describe the presence of divergent orthologs and discuss structural and functional differences in export factors between apicomplexans and other eukaryotic lineages. Undoubtedly, the use of the CRISPR/Cas9 system in high throughput screenings associated with the discovery of mRNA nuclear export complexes by proteomic analysis will contribute to identify these divergent factors. Ligand-based or structure-based strategies may be applied to investigate the potential use of these proteins as targets for new antiprotozoal agents. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13071-018-2648-4) contains supplementary material, which is available to authorized users. BioMed Central 2018-01-25 /pmc/articles/PMC5785795/ /pubmed/29370868 http://dx.doi.org/10.1186/s13071-018-2648-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Ávila, Andréa Rodrigues
Cabezas-Cruz, Alexjandro
Gissot, Mathieu
mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway
title mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway
title_full mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway
title_fullStr mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway
title_full_unstemmed mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway
title_short mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway
title_sort mrna export in the apicomplexan parasite toxoplasma gondii: emerging divergent components of a crucial pathway
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785795/
https://www.ncbi.nlm.nih.gov/pubmed/29370868
http://dx.doi.org/10.1186/s13071-018-2648-4
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