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Intraventricular infusion of clusterin ameliorated cognition and pathology in Tg6799 model of Alzheimer’s disease

BACKGROUND: Alzheimer’s disease (AD) is characterized by the deposition of amyloid-β (Aβ) in brain parenchyma and cerebral blood vessels as cerebral amyloid angiopathy (CAA). Clusterin, a chaperon protein associated with Aβ aggregation, toxicity and transport through blood–brain barrier, may play a...

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Detalles Bibliográficos
Autores principales:	Qi, Xue-Mei, Wang, Cheng, Chu, Xing-Kun, Li, Gen, Ma, Jian-Fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785859/ https://www.ncbi.nlm.nih.gov/pubmed/29370749 http://dx.doi.org/10.1186/s12868-018-0402-7

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