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Purification of 2,3-butanediol from fermentation broth: process development and techno-economic analysis

BACKGROUND: 2,3-Butanediol (2,3-BDO) is a synthetic chemical compound that also can be produced by biomass fermentation, which is gaining share in the global market as an intermediate product for numerous applications, i.e. as liquid fuel or fuel additive. Several metabolic engineering fermentation...

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Autores principales: Harvianto, Gregorius Rionugroho, Haider, Junaid, Hong, Jimin, Van Duc Long, Nguyen, Shim, Jae-Jin, Cho, Moo Hwan, Kim, Woo Kyoung, Lee, Moonyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785907/
https://www.ncbi.nlm.nih.gov/pubmed/29416563
http://dx.doi.org/10.1186/s13068-018-1013-3
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author Harvianto, Gregorius Rionugroho
Haider, Junaid
Hong, Jimin
Van Duc Long, Nguyen
Shim, Jae-Jin
Cho, Moo Hwan
Kim, Woo Kyoung
Lee, Moonyong
author_facet Harvianto, Gregorius Rionugroho
Haider, Junaid
Hong, Jimin
Van Duc Long, Nguyen
Shim, Jae-Jin
Cho, Moo Hwan
Kim, Woo Kyoung
Lee, Moonyong
author_sort Harvianto, Gregorius Rionugroho
collection PubMed
description BACKGROUND: 2,3-Butanediol (2,3-BDO) is a synthetic chemical compound that also can be produced by biomass fermentation, which is gaining share in the global market as an intermediate product for numerous applications, i.e. as liquid fuel or fuel additive. Several metabolic engineering fermentation strategies to enhance the production of 2,3-BDO were developed. However, the recovery of 2,3-BDO from its fermentation broth remains a challenge due to its low concentration and its solubility in water and other components. Thus, a cost-effective recovery process is required to deliver the required purity of 2,3-BDO. This paper presents a new process development and techno-economic analysis for 2,3-BDO purification from a fermentation broth. RESULTS: Conventional distillation and hybrid extraction-distillation (HED) processes are proposed in this study with detailed optimization and economic analysis. Particularly, a systematic solvent selection method was successfully implemented to determine a good solvent for the proposed HED configuration based on numerous experimental data obtained with each solvent candidate. NRTL and UNIQUAC property methods were evaluated to obtain binary interaction parameters of 2,3-BDO through rigorous Aspen Plus regression and validated using experimental data. Total annual cost (TAC)-based optimization was performed for each proposed configuration. Even though the HED configuration required 9.5% higher capital cost than conventional distillation, placing an extraction column before the distillation column was effective in removing water from the fermentation broth and significantly improved the overall process economics. CONCLUSIONS: Oleyl alcohol was found to be the most suitable solvent for the HED of 2,3-BDO due to its high distribution coefficient and high selectivity. The proposed HED drastically reduced reboiler duty consumption and TAC by up to 54.8 and 25.8%, respectively. The proposed design is expected to be used for the commercial scale of 2,3-BDO production from fermentation process. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13068-018-1013-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-57859072018-02-07 Purification of 2,3-butanediol from fermentation broth: process development and techno-economic analysis Harvianto, Gregorius Rionugroho Haider, Junaid Hong, Jimin Van Duc Long, Nguyen Shim, Jae-Jin Cho, Moo Hwan Kim, Woo Kyoung Lee, Moonyong Biotechnol Biofuels Research BACKGROUND: 2,3-Butanediol (2,3-BDO) is a synthetic chemical compound that also can be produced by biomass fermentation, which is gaining share in the global market as an intermediate product for numerous applications, i.e. as liquid fuel or fuel additive. Several metabolic engineering fermentation strategies to enhance the production of 2,3-BDO were developed. However, the recovery of 2,3-BDO from its fermentation broth remains a challenge due to its low concentration and its solubility in water and other components. Thus, a cost-effective recovery process is required to deliver the required purity of 2,3-BDO. This paper presents a new process development and techno-economic analysis for 2,3-BDO purification from a fermentation broth. RESULTS: Conventional distillation and hybrid extraction-distillation (HED) processes are proposed in this study with detailed optimization and economic analysis. Particularly, a systematic solvent selection method was successfully implemented to determine a good solvent for the proposed HED configuration based on numerous experimental data obtained with each solvent candidate. NRTL and UNIQUAC property methods were evaluated to obtain binary interaction parameters of 2,3-BDO through rigorous Aspen Plus regression and validated using experimental data. Total annual cost (TAC)-based optimization was performed for each proposed configuration. Even though the HED configuration required 9.5% higher capital cost than conventional distillation, placing an extraction column before the distillation column was effective in removing water from the fermentation broth and significantly improved the overall process economics. CONCLUSIONS: Oleyl alcohol was found to be the most suitable solvent for the HED of 2,3-BDO due to its high distribution coefficient and high selectivity. The proposed HED drastically reduced reboiler duty consumption and TAC by up to 54.8 and 25.8%, respectively. The proposed design is expected to be used for the commercial scale of 2,3-BDO production from fermentation process. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13068-018-1013-3) contains supplementary material, which is available to authorized users. BioMed Central 2018-01-25 /pmc/articles/PMC5785907/ /pubmed/29416563 http://dx.doi.org/10.1186/s13068-018-1013-3 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Harvianto, Gregorius Rionugroho
Haider, Junaid
Hong, Jimin
Van Duc Long, Nguyen
Shim, Jae-Jin
Cho, Moo Hwan
Kim, Woo Kyoung
Lee, Moonyong
Purification of 2,3-butanediol from fermentation broth: process development and techno-economic analysis
title Purification of 2,3-butanediol from fermentation broth: process development and techno-economic analysis
title_full Purification of 2,3-butanediol from fermentation broth: process development and techno-economic analysis
title_fullStr Purification of 2,3-butanediol from fermentation broth: process development and techno-economic analysis
title_full_unstemmed Purification of 2,3-butanediol from fermentation broth: process development and techno-economic analysis
title_short Purification of 2,3-butanediol from fermentation broth: process development and techno-economic analysis
title_sort purification of 2,3-butanediol from fermentation broth: process development and techno-economic analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785907/
https://www.ncbi.nlm.nih.gov/pubmed/29416563
http://dx.doi.org/10.1186/s13068-018-1013-3
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