Cargando…

An xQTL map integrates the genetic architecture of the human brain’s transcriptome and epigenome

We report a novel multi-omic resource generated by applying quantitative trait locus (xQTL) analyses to RNA sequence, DNA methylation, and histone acetylation data from the dorsolateral prefrontal cortex of 411 older adult individuals that have all three data types. We identify SNPs significantly as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ng, B, White, CC, Klein, H, Sieberts, SK, McCabe, C, Patrick, E, Xu, J, Yu, L, Gaiteri, C, Bennett, DA, Mostafavi, S, De Jager, PL
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785926/ https://www.ncbi.nlm.nih.gov/pubmed/28869584 http://dx.doi.org/10.1038/nn.4632

Ejemplares similares

xQTL workbench: a scalable web environment for multi-level QTL analysis
por: Arends, Danny, et al.
Publicado: (2012)

Cascading epigenomic analysis for identifying disease genes from the regulatory landscape of GWAS variants
por: Ng, Bernard, et al.
Publicado: (2021)

The Molecular and Neuropathological Consequences of Genetic Risk for Alzheimer's Dementia
por: Tasaki, Shinya, et al.
Publicado: (2018)

A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies
por: Patrick, Ellis, et al.
Publicado: (2021)

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in the aging and Alzheimer human brain
por: Klein, Hans-Ulrich, et al.
Publicado: (2018)

Network Analysis, Architecture, and Design
por: McCabe, James D
Publicado: (2007)

A multi-omic atlas of the human frontal cortex for aging and Alzheimer’s disease research
por: De Jager, Philip L., et al.
Publicado: (2018)

QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration
por: Advani, Jayshree, et al.
Publicado: (2023)

Multi-omic Directed Networks Describe Features of Gene Regulation in Aged Brains and Expand the Set of Genes Driving Cognitive Decline
por: Tasaki, Shinya, et al.
Publicado: (2018)

Benchmarking of deep neural networks for predicting personal gene expression from DNA sequence highlights shortcomings
por: Sasse, Alexander, et al.
Publicado: (2023)

The age related markers lipofuscin and apoptosis show different genetic architecture by QTL mapping in short-lived Nothobranchius fish
por: Ng'oma, Enoch, et al.
Publicado: (2014)

EPISPOT: An epigenome-driven approach for detecting and interpreting hotspots in molecular QTL studies
por: Ruffieux, Hélène, et al.
Publicado: (2021)

The complex architecture and epigenomic impact of plant T-DNA insertions
por: Jupe, Florian, et al.
Publicado: (2019)

The genetic architecture of zinc and iron content in maize grains as revealed by QTL mapping and meta-analysis
por: Jin, Tiantian, et al.
Publicado: (2013)

Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast
por: Nguyen Ba, Alex N, et al.
Publicado: (2022)

Combined QTL mapping on bi-parental immortalized heterozygous populations to detect the genetic architecture on heterosis
por: Huo, Xuexue, et al.
Publicado: (2023)

Cell-specific histone modification maps link schizophrenia risk to the neuronal epigenome
por: Girdhar, Kiran, et al.
Publicado: (2018)

The bread wheat epigenomic map reveals distinct chromatin architectural and evolutionary features of functional genetic elements
por: Li, Zijuan, et al.
Publicado: (2019)

Bayesian integrative analysis of epigenomic and transcriptomic data identifies Alzheimer's disease candidate genes and networks
por: Klein, Hans-Ulrich, et al.
Publicado: (2020)

Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain
por: Felsky, Daniel, et al.
Publicado: (2018)

Maternal environmental exposure to bisphenols and epigenome-wide DNA methylation in infant cord blood
por: McCabe, Carolyn F, et al.
Publicado: (2020)

Genetic Architecture of Sexual Selection: QTL Mapping of Male Song and Female Receiver Traits in an Acoustic Moth
por: Limousin, Denis, et al.
Publicado: (2012)

Towards the Genetic Architecture of Complex Gene Expression Traits: Challenges and Prospects for eQTL Mapping in Humans
por: Lee, Chaeyoung
Publicado: (2022)

Combining QTL Mapping and Transcriptomics to Decipher the Genetic Architecture of Phenolic Compounds Metabolism in the Conifer White Spruce
por: Laoué, Justine, et al.
Publicado: (2021)

Advances in QTL Mapping in Pigs
por: Rothschild, Max F., et al.
Publicado: (2007)

The Power of QTL Mapping with RILs
por: Takuno, Shohei, et al.
Publicado: (2012)

Statistical Methods for QTL Mapping
por: Chen, Zehua
Publicado: (2016)

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease
por: Mostafavi, Sara, et al.
Publicado: (2018)

Fine mapping of multiple QTL using combined linkage and linkage disequilibrium mapping – A comparison of single QTL and multi QTL methods
por: Uleberg, Eivind, et al.
Publicado: (2007)

Novel QTL and Meta-QTL Mapping for Major Quality Traits in Soybean
por: Chen, Heng, et al.
Publicado: (2021)

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions
por: Sieberts, Solveig K., et al.
Publicado: (2020)

An ultra-high density bin-map for rapid QTL mapping for tassel and ear architecture in a large F(2) maize population
por: Chen, Zongliang, et al.
Publicado: (2014)

QTL architecture of reproductive fitness characters in Brassica rapa
por: Dechaine, Jennifer M, et al.
Publicado: (2014)

Dissecting the eQTL Micro-Architecture in Caenorhabditis elegans
por: Sterken, Mark G., et al.
Publicado: (2020)

QTL mapping reveals the genetic architecture of loci affecting pre- and post-zygotic isolating barriers in Louisiana Iris
por: Ballerini, Evangeline S, et al.
Publicado: (2012)

Uncovering the genetic architecture of Colletotrichum lindemuthianum resistance through QTL mapping and epistatic interaction analysis in common bean
por: González, Ana M., et al.
Publicado: (2015)

QTL mapping of wheat plant architectural characteristics and their genetic relationship with seven QTLs conferring resistance to sheath blight
por: Guo, Yan, et al.
Publicado: (2017)

Dissecting the Genetic Architecture of Aphanomyces Root Rot Resistance in Lentil by QTL Mapping and Genome-Wide Association Study
por: Ma, Yu, et al.
Publicado: (2020)

Maize plant architecture trait QTL mapping and candidate gene identification based on multiple environments and double populations
por: Fei, Jianbo, et al.
Publicado: (2022)

How intrinsic dynamics and coupling architecture interact to generate bursting dynamics in a model network of respiratory conditional pacemakers
por: Gaiteri, Christopher, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_0i58hau6gi3ckqmuaiircsti0u