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Down-regulation of guanylate binding protein 1 causes mitochondrial dysfunction and cellular senescence in macrophages

Macrophage polarization is tightly associated with its metabolic reprograming and immune dysfunction. However, the intracellular molecules/pathways that connect these alterations in inflammatory macrophages remain largely unidentified. Herein, we explored the role of guanylate binding protein 1 (Gbp...

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Detalles Bibliográficos
Autores principales:	Qiu, Xiaoxue, Guo, Hong, Yang, Junshu, Ji, Yinduo, Wu, Chia-Shan, Chen, Xiaoli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785964/ https://www.ncbi.nlm.nih.gov/pubmed/29374208 http://dx.doi.org/10.1038/s41598-018-19828-7

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