HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir

Hepatitis B virus (HBV) reverse transcriptase (RT) is essential for viral replication and is an important drug target. Nonetheless, the notorious insolubility of HBV RT has hindered experimental structural studies and structure-based drug design. Here, we demonstrate that a Q151M substitution alone...

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Detalles Bibliográficos
Autores principales: Yasutake, Yoshiaki, Hattori, Shin-ichiro, Hayashi, Hironori, Matsuda, Kouki, Tamura, Noriko, Kohgo, Satoru, Maeda, Kenji, Mitsuya, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785976/
https://www.ncbi.nlm.nih.gov/pubmed/29374261
http://dx.doi.org/10.1038/s41598-018-19602-9

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