Endoscopic non-ablative fractional laser therapy in an orthotopic colon tumour model
Colorectal cancer is one of the leading causes of cancer-related deaths. Although several therapeutic management strategies are available at the early colon cancer stages, such as endoscopic mucosal or submucosal dissection, associated complications often include bleeding or bowel perforations. As a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785993/ https://www.ncbi.nlm.nih.gov/pubmed/29374265 http://dx.doi.org/10.1038/s41598-018-19792-2 |
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author | Yoo, Su Woong Oh, Gyungseok Safi, Abdul Mohaimen Hwang, Soonjoo Seo, Young-Seok Lee, Kyung-Hwa Kim, Young L. Chung, Euiheon |
author_facet | Yoo, Su Woong Oh, Gyungseok Safi, Abdul Mohaimen Hwang, Soonjoo Seo, Young-Seok Lee, Kyung-Hwa Kim, Young L. Chung, Euiheon |
author_sort | Yoo, Su Woong |
collection | PubMed |
description | Colorectal cancer is one of the leading causes of cancer-related deaths. Although several therapeutic management strategies are available at the early colon cancer stages, such as endoscopic mucosal or submucosal dissection, associated complications often include bleeding or bowel perforations. As an alternative approach, we investigated endoscopic non-ablative fractional laser (eNAFL) irradiation as a minimally invasive therapeutic modality for the treatment of early-stage colorectal cancer. By implanting SL4-DsRed colon cancer cells into the colons of the C57BL/6 mice, we developed an orthotopic colon tumour mouse model and demonstrated the early-stage tumour growth delay following the eNAFL irradiation. Additionally, we evaluated the temperature changes in the eNAFL-irradiated area using numerical simulations, and induced inflammation using histological analysis. Our results indicate a minimal thermal damage confined to the irradiated spot, sparing the adjacent tissue and alteration in the tumour microenvironment. eNAFL irradiation may be clinically useful as a minimally invasive therapeutic intervention at the early stage of tumourigenesis. In future, an optimal eNAFL therapeutic dose should be determined, in order to increase the efficacy of this approach. |
format | Online Article Text |
id | pubmed-5785993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-57859932018-02-07 Endoscopic non-ablative fractional laser therapy in an orthotopic colon tumour model Yoo, Su Woong Oh, Gyungseok Safi, Abdul Mohaimen Hwang, Soonjoo Seo, Young-Seok Lee, Kyung-Hwa Kim, Young L. Chung, Euiheon Sci Rep Article Colorectal cancer is one of the leading causes of cancer-related deaths. Although several therapeutic management strategies are available at the early colon cancer stages, such as endoscopic mucosal or submucosal dissection, associated complications often include bleeding or bowel perforations. As an alternative approach, we investigated endoscopic non-ablative fractional laser (eNAFL) irradiation as a minimally invasive therapeutic modality for the treatment of early-stage colorectal cancer. By implanting SL4-DsRed colon cancer cells into the colons of the C57BL/6 mice, we developed an orthotopic colon tumour mouse model and demonstrated the early-stage tumour growth delay following the eNAFL irradiation. Additionally, we evaluated the temperature changes in the eNAFL-irradiated area using numerical simulations, and induced inflammation using histological analysis. Our results indicate a minimal thermal damage confined to the irradiated spot, sparing the adjacent tissue and alteration in the tumour microenvironment. eNAFL irradiation may be clinically useful as a minimally invasive therapeutic intervention at the early stage of tumourigenesis. In future, an optimal eNAFL therapeutic dose should be determined, in order to increase the efficacy of this approach. Nature Publishing Group UK 2018-01-26 /pmc/articles/PMC5785993/ /pubmed/29374265 http://dx.doi.org/10.1038/s41598-018-19792-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yoo, Su Woong Oh, Gyungseok Safi, Abdul Mohaimen Hwang, Soonjoo Seo, Young-Seok Lee, Kyung-Hwa Kim, Young L. Chung, Euiheon Endoscopic non-ablative fractional laser therapy in an orthotopic colon tumour model |
title | Endoscopic non-ablative fractional laser therapy in an orthotopic colon tumour model |
title_full | Endoscopic non-ablative fractional laser therapy in an orthotopic colon tumour model |
title_fullStr | Endoscopic non-ablative fractional laser therapy in an orthotopic colon tumour model |
title_full_unstemmed | Endoscopic non-ablative fractional laser therapy in an orthotopic colon tumour model |
title_short | Endoscopic non-ablative fractional laser therapy in an orthotopic colon tumour model |
title_sort | endoscopic non-ablative fractional laser therapy in an orthotopic colon tumour model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785993/ https://www.ncbi.nlm.nih.gov/pubmed/29374265 http://dx.doi.org/10.1038/s41598-018-19792-2 |
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