Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition Confers Elimination of Pancreatic Cancer Stem Cells in Combination with Gemcitabine

Trichostatin A (TSA) possess histone deacetylase (HDAC) inhibitory potential, can reverse the deactivation of tumor suppressor genes and inhibit tumor cell proliferation. We evaluated the effect of TSA on HDAC expression, tumor cell proliferation, and cancer stem cells (CSCs) activities in pancreati...

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Detalles Bibliográficos
Autores principales: Cai, Mao-Hua, Xu, Xiao-Gang, Yan, Shi-Li, Sun, Ze, Ying, Yin, Wang, Bai-Kui, Tu, Yue-Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786009/
https://www.ncbi.nlm.nih.gov/pubmed/29374219
http://dx.doi.org/10.1038/s41598-018-20004-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786009/
https://www.ncbi.nlm.nih.gov/pubmed/29374219
http://dx.doi.org/10.1038/s41598-018-20004-0

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