GWAS of epigenetic aging rates in blood reveals a critical role for TERT

DNA methylation age is an accurate biomarker of chronological age and predicts lifespan, but its underlying molecular mechanisms are unknown. In this genome-wide association study of 9907 individuals, we find gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (I...

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Detalles Bibliográficos
Autores principales: Lu, Ake T., Xue, Luting, Salfati, Elias L., Chen, Brian H., Ferrucci, Luigi, Levy, Daniel, Joehanes, Roby, Murabito, Joanne M., Kiel, Douglas P., Tsai, Pei-Chien, Yet, Idil, Bell, Jordana T., Mangino, Massimo, Tanaka, Toshiko, McRae, Allan F., Marioni, Riccardo E., Visscher, Peter M., Wray, Naomi R., Deary, Ian J., Levine, Morgan E., Quach, Austin, Assimes, Themistocles, Tsao, Philip S., Absher, Devin, Stewart, James D., Li, Yun, Reiner, Alex P., Hou, Lifang, Baccarelli, Andrea A., Whitsel, Eric A., Aviv, Abraham, Cardona, Alexia, Day, Felix R., Wareham, Nicholas J., Perry, John R. B., Ong, Ken K., Raj, Kenneth, Lunetta, Kathryn L., Horvath, Steve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786029/
https://www.ncbi.nlm.nih.gov/pubmed/29374233
http://dx.doi.org/10.1038/s41467-017-02697-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786029/
https://www.ncbi.nlm.nih.gov/pubmed/29374233
http://dx.doi.org/10.1038/s41467-017-02697-5

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