Cargando…

GWAS of epigenetic aging rates in blood reveals a critical role for TERT

DNA methylation age is an accurate biomarker of chronological age and predicts lifespan, but its underlying molecular mechanisms are unknown. In this genome-wide association study of 9907 individuals, we find gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (I...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Ake T., Xue, Luting, Salfati, Elias L., Chen, Brian H., Ferrucci, Luigi, Levy, Daniel, Joehanes, Roby, Murabito, Joanne M., Kiel, Douglas P., Tsai, Pei-Chien, Yet, Idil, Bell, Jordana T., Mangino, Massimo, Tanaka, Toshiko, McRae, Allan F., Marioni, Riccardo E., Visscher, Peter M., Wray, Naomi R., Deary, Ian J., Levine, Morgan E., Quach, Austin, Assimes, Themistocles, Tsao, Philip S., Absher, Devin, Stewart, James D., Li, Yun, Reiner, Alex P., Hou, Lifang, Baccarelli, Andrea A., Whitsel, Eric A., Aviv, Abraham, Cardona, Alexia, Day, Felix R., Wareham, Nicholas J., Perry, John R. B., Ong, Ken K., Raj, Kenneth, Lunetta, Kathryn L., Horvath, Steve
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786029/ https://www.ncbi.nlm.nih.gov/pubmed/29374233 http://dx.doi.org/10.1038/s41467-017-02697-5

Ejemplares similares

DNA methylation-based estimator of telomere length
por: Lu, Ake T., et al.
Publicado: (2019)

Associations between a Genetic Risk Score for Clinical CAD and Early Stage Lesions in the Coronary Artery and the Aorta
por: Salfati, Elias L., et al.
Publicado: (2016)

DNA methylation GrimAge strongly predicts lifespan and healthspan
por: Lu, Ake T., et al.
Publicado: (2019)

Epigenetic clock analysis of diet, exercise, education, and lifestyle factors
por: Quach, Austin, et al.
Publicado: (2017)

Blood DNA methylation sites predict death risk in a longitudinal study of 12,300 individuals
por: Colicino, Elena, et al.
Publicado: (2020)

DNA methylation age of blood predicts all-cause mortality in later life
por: Marioni, Riccardo E, et al.
Publicado: (2015)

Transcriptome-wide association study of inflammatory biologic age
por: Lin, Honghuang, et al.
Publicado: (2017)

Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example
por: Goldstein, Benjamin A., et al.
Publicado: (2014)

Corrigendum: Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example
por: Goldstein, Benjamin A., et al.
Publicado: (2015)

coMET: visualisation of regional epigenome-wide association scan results and DNA co-methylation patterns
por: Martin, Tiphaine C, et al.
Publicado: (2015)

Genetic Influences on Metabolite Levels: A Comparison across Metabolomic Platforms
por: Yet, Idil, et al.
Publicado: (2016)

An epigenetic biomarker of aging for lifespan and healthspan
por: Levine, Morgan E., et al.
Publicado: (2018)

DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative
por: Levine, Morgan E., et al.
Publicado: (2015)

DNA methylation-based measures of biological age: meta-analysis predicting time to death
por: Chen, Brian H., et al.
Publicado: (2016)

Genome-wide association with bone mass and geometry in the Framingham Heart Study
por: Kiel, Douglas P, et al.
Publicado: (2007)

Genotype effects contribute to variation in longitudinal methylome patterns in older people
por: Zhang, Qian, et al.
Publicado: (2018)

Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults
por: Guarischi-Sousa, Rodrigo, et al.
Publicado: (2023)

GENOME-WIDE ASSOCIATION META-ANALYSIS OF PHYSICAL PERFORMANCE IN OLDER ADULTS
por: Santanasto, Adam, et al.
Publicado: (2022)

Epigenome-wide association study of whole blood gene expression in Framingham Heart Study participants provides molecular insight into the potential role of CHRNA5 in cigarette smoking-related lung diseases
por: Yao, Chen, et al.
Publicado: (2021)

Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations
por: Shah, Sonia, et al.
Publicado: (2015)

The epigenetic clock and telomere length are independently associated with chronological age and mortality
por: Marioni, Riccardo E, et al.
Publicado: (2016)

The epigenetic clock and telomere length are independently associated with chronological age and mortality
por: Marioni, Riccardo E, et al.
Publicado: (2018)

Heritable components of the human fecal microbiome are associated with visceral fat
por: Beaumont, Michelle, et al.
Publicado: (2016)

Leukocyte telomere length, T cell composition and DNA methylation age
por: Chen, Brian H., et al.
Publicado: (2017)

Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci
por: Sazonova, Olga, et al.
Publicado: (2015)

Assisted clustering of gene expression data using regulatory data from partially overlapping sets of individuals
por: Jiang, Wenqing, et al.
Publicado: (2022)

INFLAMMATORY BIOMARKERS ASSOCIATED WITH COGNITIVE FUNCTION AND DEMENTIA
por: Chen, Jiachen, et al.
Publicado: (2022)

Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons
por: Pilling, L. C., et al.
Publicado: (2015)

Examining the Impact of Imputation Errors on Fine-Mapping Using DNA Methylation QTL as a Model Trait
por: Chundru, V. Kartik, et al.
Publicado: (2019)

DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases
por: Ligthart, Symen, et al.
Publicado: (2016)

Rare genetic variants underlie outlying levels of DNA methylation and gene-expression
por: Chundru, V Kartik, et al.
Publicado: (2023)

Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
por: Jhun, Min-A, et al.
Publicado: (2021)

A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
por: Jhun, Min-A, et al.
Publicado: (2021)

Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation
por: Gioia, Marco Di, et al.
Publicado: (2019)

Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits
por: Wu, Yang, et al.
Publicado: (2018)

Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study
por: Lankester, Joanna, et al.
Publicado: (2021)

Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies
por: Hedman, Åsa K., et al.
Publicado: (2017)

Getting closer to the clinic
por: Tanaka, Toshiko, et al.
Publicado: (2022)

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood
por: Qi, Ting, et al.
Publicado: (2018)

Whole Blood Gene Expression and Atrial Fibrillation: The Framingham Heart Study
por: Lin, Honghuang, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_trimfjnho079a22ii4l2mqa9gl