Development and characterisation of a panel of phosphatidylinositide 3-kinase – mammalian target of rapamycin inhibitor resistant lung cancer cell lines

The PI3K-mTOR pathway is involved in regulating all hallmarks of cancer, and is often dysregulated in NSCLC, making it an attractive therapeutic target in this setting. Acquired resistance to PI3K-mTOR inhibition is a major hurdle to overcome in the success of PI3K-mTOR targeted agents. H460, A549,...

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Detalles Bibliográficos
Autores principales: Heavey, Susan, Dowling, Paul, Moore, Gillian, Barr, Martin P., Kelly, Niamh, Maher, Stephen G., Cuffe, Sinead, Finn, Stephen P., O’Byrne, Kenneth J., Gately, Kathy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786033/
https://www.ncbi.nlm.nih.gov/pubmed/29374181
http://dx.doi.org/10.1038/s41598-018-19688-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786033/
https://www.ncbi.nlm.nih.gov/pubmed/29374181
http://dx.doi.org/10.1038/s41598-018-19688-1

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