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Tissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis

Cancer patients with Tissue Factor (TF)-bearing MPs have been presented association with increased risk of venous thromboembolism (VTE), but results of these studies have not been consistent. We aimed to conduct a meta-analysis to assess the relationship between TF-bearing MPs and risk of VTE in pat...

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Detalles Bibliográficos
Autores principales: Cui, Chan-juan, Wang, Guo-jing, Yang, Shuo, Huang, Sheng-kai, Qiao, Rui, Cui, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786054/
https://www.ncbi.nlm.nih.gov/pubmed/29374212
http://dx.doi.org/10.1038/s41598-018-19889-8
Descripción
Sumario:Cancer patients with Tissue Factor (TF)-bearing MPs have been presented association with increased risk of venous thromboembolism (VTE), but results of these studies have not been consistent. We aimed to conduct a meta-analysis to assess the relationship between TF-bearing MPs and risk of VTE in patients with cancer. PubMed, Web of Science and EMBASE Databases were systematically retrieved up to1(th) June 2017. Two case-control studies and four cohort studies met the entry requirements in this analysis. The summary odd ratio (OR) were estimated by a random effect model. The overall OR was 1.76 (95% CI: 1.21–2.56, I(2) = 62.0%). The OR of case-control studies was 3.41 (95% CI: 1.45–8.02, I(2) = 0.0%) and that of cohort studies was1.53 (95% CI: 1.05–2.24, I(2) = 66.1%). The association between TF-bearing MPs and the risk of VTE in cancer patients was found in this meta-analysis. Publication bias testing and sensitivity subgroup analysis suggested that results of this meta-analysis were robustness. In conclusion, TF-bearing MPs were associated with increased risk of VTE in patients with cancer. Whereas, more well-designed studies and more comprehensive adjustments for confounders in further studies are warranted to affirm the association.