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Growth across life course and cardiovascular risk markers in 18-year-old adolescents: the 1993 Pelotas birth cohort

OBJECTIVE: To evaluate the association between growth trajectories from birth to adolescence and cardiovascular risk marker levels at age 18 years in a population-based cohort. In order to disentangle the effect of weight gain from that of height gain, growth was analysed using conditional weight re...

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Autores principales: Buffarini, Romina, Restrepo-Méndez, María Clara, Silveira, Vera Maria, Gonçalves, Helen D, Oliveira, Isabel O, Menezes, Ana Maria, Formoso Assunção, Maria Cecília
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786082/
https://www.ncbi.nlm.nih.gov/pubmed/29362264
http://dx.doi.org/10.1136/bmjopen-2017-019164
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author Buffarini, Romina
Restrepo-Méndez, María Clara
Silveira, Vera Maria
Gonçalves, Helen D
Oliveira, Isabel O
Menezes, Ana Maria
Formoso Assunção, Maria Cecília
author_facet Buffarini, Romina
Restrepo-Méndez, María Clara
Silveira, Vera Maria
Gonçalves, Helen D
Oliveira, Isabel O
Menezes, Ana Maria
Formoso Assunção, Maria Cecília
author_sort Buffarini, Romina
collection PubMed
description OBJECTIVE: To evaluate the association between growth trajectories from birth to adolescence and cardiovascular risk marker levels at age 18 years in a population-based cohort. In order to disentangle the effect of weight gain from that of height gain, growth was analysed using conditional weight relative to linear growth (CWh) and conditional length/height (CH). DESIGN: Prospective study. SETTING: 1993 Pelotas birth cohort, Southern Brazil. PARTICIPANTS: Individuals who have been followed up from birth to adolescence (at birth, 1, 4, 11, 15 and 18 years). PRIMARY OUTCOME MEASURES: C-reactive protein (CRP), total cholesterol (TC), LDL cholesterol (LDL-C), HDL-cholesterol (HDL-C), triglycerides (TGL), systolic and diastolic blood pressure (SBP and DBP), body mass index (BMI) and waist circumference (WC). RESULTS: In both sexes, greater CWh at 1 year was positively associated with BMI and WC, whereas greater CWh at most age periods in childhood and adolescence predicted higher CRP, TC, LDL-C, TGL, SBP, DBP, BMI and WC levels, as well as lower HDL-C level. Higher CH during infancy and childhood was positively related with SBP in boys and girls, and with BMI and WC only in boys. CONCLUSION: Our study shows that rapid weight gain from 1 year onwards is positively associated with several markers of cardiovascular risk at 18 years. Overall, our results for the first year of life add evidence to the ‘first 1000 days initiative’ suggesting that prevention of excessive weight gain in childhood might be important in reducing subsequent cardiovascular risk.
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spelling pubmed-57860822018-01-31 Growth across life course and cardiovascular risk markers in 18-year-old adolescents: the 1993 Pelotas birth cohort Buffarini, Romina Restrepo-Méndez, María Clara Silveira, Vera Maria Gonçalves, Helen D Oliveira, Isabel O Menezes, Ana Maria Formoso Assunção, Maria Cecília BMJ Open Epidemiology OBJECTIVE: To evaluate the association between growth trajectories from birth to adolescence and cardiovascular risk marker levels at age 18 years in a population-based cohort. In order to disentangle the effect of weight gain from that of height gain, growth was analysed using conditional weight relative to linear growth (CWh) and conditional length/height (CH). DESIGN: Prospective study. SETTING: 1993 Pelotas birth cohort, Southern Brazil. PARTICIPANTS: Individuals who have been followed up from birth to adolescence (at birth, 1, 4, 11, 15 and 18 years). PRIMARY OUTCOME MEASURES: C-reactive protein (CRP), total cholesterol (TC), LDL cholesterol (LDL-C), HDL-cholesterol (HDL-C), triglycerides (TGL), systolic and diastolic blood pressure (SBP and DBP), body mass index (BMI) and waist circumference (WC). RESULTS: In both sexes, greater CWh at 1 year was positively associated with BMI and WC, whereas greater CWh at most age periods in childhood and adolescence predicted higher CRP, TC, LDL-C, TGL, SBP, DBP, BMI and WC levels, as well as lower HDL-C level. Higher CH during infancy and childhood was positively related with SBP in boys and girls, and with BMI and WC only in boys. CONCLUSION: Our study shows that rapid weight gain from 1 year onwards is positively associated with several markers of cardiovascular risk at 18 years. Overall, our results for the first year of life add evidence to the ‘first 1000 days initiative’ suggesting that prevention of excessive weight gain in childhood might be important in reducing subsequent cardiovascular risk. BMJ Publishing Group 2018-01-23 /pmc/articles/PMC5786082/ /pubmed/29362264 http://dx.doi.org/10.1136/bmjopen-2017-019164 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
spellingShingle Epidemiology
Buffarini, Romina
Restrepo-Méndez, María Clara
Silveira, Vera Maria
Gonçalves, Helen D
Oliveira, Isabel O
Menezes, Ana Maria
Formoso Assunção, Maria Cecília
Growth across life course and cardiovascular risk markers in 18-year-old adolescents: the 1993 Pelotas birth cohort
title Growth across life course and cardiovascular risk markers in 18-year-old adolescents: the 1993 Pelotas birth cohort
title_full Growth across life course and cardiovascular risk markers in 18-year-old adolescents: the 1993 Pelotas birth cohort
title_fullStr Growth across life course and cardiovascular risk markers in 18-year-old adolescents: the 1993 Pelotas birth cohort
title_full_unstemmed Growth across life course and cardiovascular risk markers in 18-year-old adolescents: the 1993 Pelotas birth cohort
title_short Growth across life course and cardiovascular risk markers in 18-year-old adolescents: the 1993 Pelotas birth cohort
title_sort growth across life course and cardiovascular risk markers in 18-year-old adolescents: the 1993 pelotas birth cohort
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786082/
https://www.ncbi.nlm.nih.gov/pubmed/29362264
http://dx.doi.org/10.1136/bmjopen-2017-019164
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