A model for cooperative gating of L-type Ca(2+) channels and its effects on cardiac alternans dynamics

In ventricular myocytes, membrane depolarization during the action potential (AP) causes synchronous activation of multiple L-type Ca(V)1.2 channels (LTCCs), which trigger the release of calcium (Ca(2+)) from the sarcoplasmic reticulum (SR). This results in an increase in intracellular Ca(2+) (Ca(i)...

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Detalles Bibliográficos
Autores principales: Sato, Daisuke, Dixon, Rose E., Santana, Luis F., Navedo, Manuel F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786340/
https://www.ncbi.nlm.nih.gov/pubmed/29338006
http://dx.doi.org/10.1371/journal.pcbi.1005906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786340/
https://www.ncbi.nlm.nih.gov/pubmed/29338006
http://dx.doi.org/10.1371/journal.pcbi.1005906

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