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A model for cooperative gating of L-type Ca(2+) channels and its effects on cardiac alternans dynamics
In ventricular myocytes, membrane depolarization during the action potential (AP) causes synchronous activation of multiple L-type Ca(V)1.2 channels (LTCCs), which trigger the release of calcium (Ca(2+)) from the sarcoplasmic reticulum (SR). This results in an increase in intracellular Ca(2+) (Ca(i)...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786340/ https://www.ncbi.nlm.nih.gov/pubmed/29338006 http://dx.doi.org/10.1371/journal.pcbi.1005906 |