Case Report of Bone Marrow-Sparing Proton Therapy Craniospinal Irradiation for Central Nervous System Myelomatosis

Central nervous system (CNS) involvement is rare but it is an increasingly recognized complication of the multiple myeloma. The craniospinal radiotherapy is a standard treatment option, however, it may be challenging to deliver due to hematologic toxicity in the patients with multiple prior systemic...

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Autores principales: Kauffmann, Greg, Buerki, Robin A, Lukas, Rimas V, Gondi, Vinai, Chmura, Steven J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2017
Materias:
Medical Physics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786350/
https://www.ncbi.nlm.nih.gov/pubmed/29387514
http://dx.doi.org/10.7759/cureus.1885
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author Kauffmann, Greg
Buerki, Robin A
Lukas, Rimas V
Gondi, Vinai
Chmura, Steven J
author_facet Kauffmann, Greg
Buerki, Robin A
Lukas, Rimas V
Gondi, Vinai
Chmura, Steven J
author_sort Kauffmann, Greg
collection PubMed
description Central nervous system (CNS) involvement is rare but it is an increasingly recognized complication of the multiple myeloma. The craniospinal radiotherapy is a standard treatment option, however, it may be challenging to deliver due to hematologic toxicity in the patients with multiple prior systemic therapies. We report a case of CNS myelomatosis in a patient with prior stem cell transplant multiple systemic therapies treated with bone marrow-sparing proton therapy craniospinal irradiation, with the dramatic clinical response and minimal hematologic toxicity.
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spelling pubmed-57863502018-01-31 Case Report of Bone Marrow-Sparing Proton Therapy Craniospinal Irradiation for Central Nervous System Myelomatosis Kauffmann, Greg Buerki, Robin A Lukas, Rimas V Gondi, Vinai Chmura, Steven J Cureus Medical Physics Central nervous system (CNS) involvement is rare but it is an increasingly recognized complication of the multiple myeloma. The craniospinal radiotherapy is a standard treatment option, however, it may be challenging to deliver due to hematologic toxicity in the patients with multiple prior systemic therapies. We report a case of CNS myelomatosis in a patient with prior stem cell transplant multiple systemic therapies treated with bone marrow-sparing proton therapy craniospinal irradiation, with the dramatic clinical response and minimal hematologic toxicity. Cureus 2017-11-28 /pmc/articles/PMC5786350/ /pubmed/29387514 http://dx.doi.org/10.7759/cureus.1885 Text en Copyright © 2017, Kauffmann et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Medical Physics
Kauffmann, Greg
Buerki, Robin A
Lukas, Rimas V
Gondi, Vinai
Chmura, Steven J
Case Report of Bone Marrow-Sparing Proton Therapy Craniospinal Irradiation for Central Nervous System Myelomatosis
title Case Report of Bone Marrow-Sparing Proton Therapy Craniospinal Irradiation for Central Nervous System Myelomatosis
title_full Case Report of Bone Marrow-Sparing Proton Therapy Craniospinal Irradiation for Central Nervous System Myelomatosis
title_fullStr Case Report of Bone Marrow-Sparing Proton Therapy Craniospinal Irradiation for Central Nervous System Myelomatosis
title_full_unstemmed Case Report of Bone Marrow-Sparing Proton Therapy Craniospinal Irradiation for Central Nervous System Myelomatosis
title_short Case Report of Bone Marrow-Sparing Proton Therapy Craniospinal Irradiation for Central Nervous System Myelomatosis
title_sort case report of bone marrow-sparing proton therapy craniospinal irradiation for central nervous system myelomatosis
topic Medical Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786350/
https://www.ncbi.nlm.nih.gov/pubmed/29387514
http://dx.doi.org/10.7759/cureus.1885
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