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Thickness of carotid intima and epicardial fat in rosacea: a cross-sectional study

BACKGROUND: Rosacea is a chronic facial skin disease associated with excessive inflammatory response to various triggers. Although some studies have supported the increased risk of cardiovascular diseases in rosacea, it has not been completely accepted. OBJECTIVE: We aimed to investigate epicardial...

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Autores principales: Belli, Asli Akin, Altun, Ilknur, Altun, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786397/
https://www.ncbi.nlm.nih.gov/pubmed/29364439
http://dx.doi.org/10.1590/abd1806-4841.20176832
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author Belli, Asli Akin
Altun, Ilknur
Altun, Ibrahim
author_facet Belli, Asli Akin
Altun, Ilknur
Altun, Ibrahim
author_sort Belli, Asli Akin
collection PubMed
description BACKGROUND: Rosacea is a chronic facial skin disease associated with excessive inflammatory response to various triggers. Although some studies have supported the increased risk of cardiovascular diseases in rosacea, it has not been completely accepted. OBJECTIVE: We aimed to investigate epicardial fat thickness and carotid intima-media thickness as cardiovascular risk predictors in rosacea patients. METHODS: We conducted a cross-sectional study including 40 rosacea patients and 40 controls. Demographic data, epicardial fat thickness, carotid intima-media thickness, lipid parameters, biochemical parameters, presence of insulin resistance, and presence of metabolic syndrome of the participants were recorded. RESULTS: Forty rosacea patients (31 female and 9 male) and 40 controls (30 female and 10 male) were enrolled in the study. Rosacea patients had significantly higher epicardial fat thickness and carotid intima-media thickness volumes than controls (P<0.001). In the multivariate logistic regression analysis, epicardial fat thickness was independently related to presence of rosacea (P<0.001, OR=13.31). In the multiple linear regression analysis, the epicardial fat thickness was independently associated with rosacea (β= 0.47, P<0.001), carotid intima-media thickness (β= 0.36, P<0.001), and systolic blood pressure (β=0.19, P=0.015) and the carotid intima-media thickness was independently associated with epicardial fat thickness (β= 0.6, P<0.001). The epicardial fat thickness levels were correlated with carotid intima-media thickness (r=0.63, P<0.001), LDL (r=0.23, P=0.037), systolic blood pressure (r=0.45, P<0.001), and diastolic blood pressure levels (r=0.37, P=0.001). The carotid intima-media thickness levels were correlated with epicardial fat thickness (r=0.63, P<0.001), systolic blood pressure (r=0.04, P<0.001), and diastolic blood pressure levels (r=0.27, P=0.016). STUDY LIMITATIONS: The small number of participants. CONCLUSIONS: Examination and follow-up of rosacea patients for cardiovascular diseases may be recommended practices.
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spelling pubmed-57863972018-02-01 Thickness of carotid intima and epicardial fat in rosacea: a cross-sectional study Belli, Asli Akin Altun, Ilknur Altun, Ibrahim An Bras Dermatol Investigation BACKGROUND: Rosacea is a chronic facial skin disease associated with excessive inflammatory response to various triggers. Although some studies have supported the increased risk of cardiovascular diseases in rosacea, it has not been completely accepted. OBJECTIVE: We aimed to investigate epicardial fat thickness and carotid intima-media thickness as cardiovascular risk predictors in rosacea patients. METHODS: We conducted a cross-sectional study including 40 rosacea patients and 40 controls. Demographic data, epicardial fat thickness, carotid intima-media thickness, lipid parameters, biochemical parameters, presence of insulin resistance, and presence of metabolic syndrome of the participants were recorded. RESULTS: Forty rosacea patients (31 female and 9 male) and 40 controls (30 female and 10 male) were enrolled in the study. Rosacea patients had significantly higher epicardial fat thickness and carotid intima-media thickness volumes than controls (P<0.001). In the multivariate logistic regression analysis, epicardial fat thickness was independently related to presence of rosacea (P<0.001, OR=13.31). In the multiple linear regression analysis, the epicardial fat thickness was independently associated with rosacea (β= 0.47, P<0.001), carotid intima-media thickness (β= 0.36, P<0.001), and systolic blood pressure (β=0.19, P=0.015) and the carotid intima-media thickness was independently associated with epicardial fat thickness (β= 0.6, P<0.001). The epicardial fat thickness levels were correlated with carotid intima-media thickness (r=0.63, P<0.001), LDL (r=0.23, P=0.037), systolic blood pressure (r=0.45, P<0.001), and diastolic blood pressure levels (r=0.37, P=0.001). The carotid intima-media thickness levels were correlated with epicardial fat thickness (r=0.63, P<0.001), systolic blood pressure (r=0.04, P<0.001), and diastolic blood pressure levels (r=0.27, P=0.016). STUDY LIMITATIONS: The small number of participants. CONCLUSIONS: Examination and follow-up of rosacea patients for cardiovascular diseases may be recommended practices. Sociedade Brasileira de Dermatologia 2017 /pmc/articles/PMC5786397/ /pubmed/29364439 http://dx.doi.org/10.1590/abd1806-4841.20176832 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way.
spellingShingle Investigation
Belli, Asli Akin
Altun, Ilknur
Altun, Ibrahim
Thickness of carotid intima and epicardial fat in rosacea: a cross-sectional study
title Thickness of carotid intima and epicardial fat in rosacea: a cross-sectional study
title_full Thickness of carotid intima and epicardial fat in rosacea: a cross-sectional study
title_fullStr Thickness of carotid intima and epicardial fat in rosacea: a cross-sectional study
title_full_unstemmed Thickness of carotid intima and epicardial fat in rosacea: a cross-sectional study
title_short Thickness of carotid intima and epicardial fat in rosacea: a cross-sectional study
title_sort thickness of carotid intima and epicardial fat in rosacea: a cross-sectional study
topic Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786397/
https://www.ncbi.nlm.nih.gov/pubmed/29364439
http://dx.doi.org/10.1590/abd1806-4841.20176832
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