Can non‐clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium

BACKGROUND AND PURPOSE: Translation of non‐clinical markers of delayed ventricular repolarization to clinical prolongation of the QT interval corrected for heart rate (QTc) (a biomarker for torsades de pointes proarrhythmia) remains an issue in drug discovery and regulatory evaluations. We retrospec...

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Detalles Bibliográficos
Autores principales: Park, Eunjung, Gintant, Gary A, Bi, Daoqin, Kozeli, Devi, Pettit, Syril D, Pierson, Jennifer B, Skinner, Matthew, Willard, James, Wisialowski, Todd, Koerner, John, Valentin, Jean‐Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786459/
https://www.ncbi.nlm.nih.gov/pubmed/29181850
http://dx.doi.org/10.1111/bph.14101

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