The Potential Role of circRNA in Tumor Immunity Regulation and Immunotherapy

Non-coding RNAs (ncRNAs) can be divided into circular non-coding RNAs (circRNAs) and linear ncRNAs. ncRNAs exist in different cell types, including normal cells, tumor cells and immunocytes. Linear ncRNAs, such as long ncRNAs and microRNAs, have been found to play important roles in the regulation o...

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Autores principales: Xu, Zihao, Li, Peiyao, Fan, Li, Wu, Minghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786515/
https://www.ncbi.nlm.nih.gov/pubmed/29403493
http://dx.doi.org/10.3389/fimmu.2018.00009
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author Xu, Zihao
Li, Peiyao
Fan, Li
Wu, Minghua
author_facet Xu, Zihao
Li, Peiyao
Fan, Li
Wu, Minghua
author_sort Xu, Zihao
collection PubMed
description Non-coding RNAs (ncRNAs) can be divided into circular non-coding RNAs (circRNAs) and linear ncRNAs. ncRNAs exist in different cell types, including normal cells, tumor cells and immunocytes. Linear ncRNAs, such as long ncRNAs and microRNAs, have been found to play important roles in the regulation of tumor immunity and immunotherapy; however, the functions of circRNAs in tumor immunity and immunotherapy are less known. Here, we review the current status of ncRNAs in the regulation of tumor immunity and immunotherapy and emphatically discuss the potential roles of circRNAs as tumor antigens in the regulation of tumor immunity and immunotherapy.
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spelling pubmed-57865152018-02-05 The Potential Role of circRNA in Tumor Immunity Regulation and Immunotherapy Xu, Zihao Li, Peiyao Fan, Li Wu, Minghua Front Immunol Immunology Non-coding RNAs (ncRNAs) can be divided into circular non-coding RNAs (circRNAs) and linear ncRNAs. ncRNAs exist in different cell types, including normal cells, tumor cells and immunocytes. Linear ncRNAs, such as long ncRNAs and microRNAs, have been found to play important roles in the regulation of tumor immunity and immunotherapy; however, the functions of circRNAs in tumor immunity and immunotherapy are less known. Here, we review the current status of ncRNAs in the regulation of tumor immunity and immunotherapy and emphatically discuss the potential roles of circRNAs as tumor antigens in the regulation of tumor immunity and immunotherapy. Frontiers Media S.A. 2018-01-22 /pmc/articles/PMC5786515/ /pubmed/29403493 http://dx.doi.org/10.3389/fimmu.2018.00009 Text en Copyright © 2018 Xu, Li, Fan and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Xu, Zihao
Li, Peiyao
Fan, Li
Wu, Minghua
The Potential Role of circRNA in Tumor Immunity Regulation and Immunotherapy
title The Potential Role of circRNA in Tumor Immunity Regulation and Immunotherapy
title_full The Potential Role of circRNA in Tumor Immunity Regulation and Immunotherapy
title_fullStr The Potential Role of circRNA in Tumor Immunity Regulation and Immunotherapy
title_full_unstemmed The Potential Role of circRNA in Tumor Immunity Regulation and Immunotherapy
title_short The Potential Role of circRNA in Tumor Immunity Regulation and Immunotherapy
title_sort potential role of circrna in tumor immunity regulation and immunotherapy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786515/
https://www.ncbi.nlm.nih.gov/pubmed/29403493
http://dx.doi.org/10.3389/fimmu.2018.00009
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