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Lipidomics unveils the complexity of the lipidome in metabolic diseases
Dysregulation of lipid metabolism is responsible for pathologies of human diseases including metabolic diseases. Recent advances in lipidomics analysis allow for the targeted and untargeted identification of lipid species and for their quantification in normal and diseased conditions. Herein, this r...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786598/ https://www.ncbi.nlm.nih.gov/pubmed/29374337 http://dx.doi.org/10.1186/s40169-018-0182-9 |
| _version_ | 1783295806725423104 |
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| author | Lydic, Todd A. Goo, Young-Hwa |
| author_facet | Lydic, Todd A. Goo, Young-Hwa |
| author_sort | Lydic, Todd A. |
| collection | PubMed |
| description | Dysregulation of lipid metabolism is responsible for pathologies of human diseases including metabolic diseases. Recent advances in lipidomics analysis allow for the targeted and untargeted identification of lipid species and for their quantification in normal and diseased conditions. Herein, this review provides a brief introduction to lipidomics, highlights its application to characterize the lipidome at the cellular and physiological levels under different biological conditions, and discusses the potential for the use of lipidomics in the discovery of biomarkers. |
| format | Online Article Text |
| id | pubmed-5786598 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Springer Berlin Heidelberg |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-57865982018-02-05 Lipidomics unveils the complexity of the lipidome in metabolic diseases Lydic, Todd A. Goo, Young-Hwa Clin Transl Med Review Dysregulation of lipid metabolism is responsible for pathologies of human diseases including metabolic diseases. Recent advances in lipidomics analysis allow for the targeted and untargeted identification of lipid species and for their quantification in normal and diseased conditions. Herein, this review provides a brief introduction to lipidomics, highlights its application to characterize the lipidome at the cellular and physiological levels under different biological conditions, and discusses the potential for the use of lipidomics in the discovery of biomarkers. Springer Berlin Heidelberg 2018-01-26 /pmc/articles/PMC5786598/ /pubmed/29374337 http://dx.doi.org/10.1186/s40169-018-0182-9 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| spellingShingle | Review Lydic, Todd A. Goo, Young-Hwa Lipidomics unveils the complexity of the lipidome in metabolic diseases |
| title | Lipidomics unveils the complexity of the lipidome in metabolic diseases |
| title_full | Lipidomics unveils the complexity of the lipidome in metabolic diseases |
| title_fullStr | Lipidomics unveils the complexity of the lipidome in metabolic diseases |
| title_full_unstemmed | Lipidomics unveils the complexity of the lipidome in metabolic diseases |
| title_short | Lipidomics unveils the complexity of the lipidome in metabolic diseases |
| title_sort | lipidomics unveils the complexity of the lipidome in metabolic diseases |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786598/ https://www.ncbi.nlm.nih.gov/pubmed/29374337 http://dx.doi.org/10.1186/s40169-018-0182-9 |
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