Association between Thrombophilic Genes Polymorphisms and Recurrent Pregnancy Loss Susceptibility in the Iranian Population: a Systematic Review and Meta-Analysis

Studies have indicated that thrombophilic genes polymorphisms are associated with recurrent pregnancy loss (RPL) in the Iranian population. We aimed to evaluate the precise association between thrombophilic genes polymorphisms (MTHFR C677T, MTHFR A1298C, Prothrombin G20210A, FVL G1691A, and PAI-1 4G...

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Autores principales: Kamali, Mahdieh, Hantoushzadeh, Sedigheh, Borna, Sedigheh, Neamatzadeh, Hossein, Mazaheri, Mahta, Noori-Shadkam, Mahmood, Haghighi, Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pasteur Institute 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786662/
https://www.ncbi.nlm.nih.gov/pubmed/28734273
http://dx.doi.org/10.22034/ibj.22.2.78
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author Kamali, Mahdieh
Hantoushzadeh, Sedigheh
Borna, Sedigheh
Neamatzadeh, Hossein
Mazaheri, Mahta
Noori-Shadkam, Mahmood
Haghighi, Fatemeh
author_facet Kamali, Mahdieh
Hantoushzadeh, Sedigheh
Borna, Sedigheh
Neamatzadeh, Hossein
Mazaheri, Mahta
Noori-Shadkam, Mahmood
Haghighi, Fatemeh
author_sort Kamali, Mahdieh
collection PubMed
description Studies have indicated that thrombophilic genes polymorphisms are associated with recurrent pregnancy loss (RPL) in the Iranian population. We aimed to evaluate the precise association between thrombophilic genes polymorphisms (MTHFR C677T, MTHFR A1298C, Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G) and RPL risk in the Iranian population. PubMed, Web of Science, Google Scholar, and ISC were searched for eligible articles published up to April 1, 2017. In total, 37 case-control studies in 18 relevant publications were selected: 1,199, 1,194, 630, 830, and 955 RPL cases and 1,079, 1079, 594, 794, and 499 controls for MTHFR C677T, MTHFR A1298C,Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G, respectively. The results indicated a significant increased risk of RPL in all genetic models in the population. Also, Prothrombin G20210A and FVL G1691A as well as PAI-1 4G/5G polymorphisms were associated with RPL risk in the Iranian population. Hence, thrombophilic genes polymorphisms are associated with an increased RPL risk in the Iranian population.
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spelling pubmed-57866622018-03-01 Association between Thrombophilic Genes Polymorphisms and Recurrent Pregnancy Loss Susceptibility in the Iranian Population: a Systematic Review and Meta-Analysis Kamali, Mahdieh Hantoushzadeh, Sedigheh Borna, Sedigheh Neamatzadeh, Hossein Mazaheri, Mahta Noori-Shadkam, Mahmood Haghighi, Fatemeh Iran Biomed J Review Article Studies have indicated that thrombophilic genes polymorphisms are associated with recurrent pregnancy loss (RPL) in the Iranian population. We aimed to evaluate the precise association between thrombophilic genes polymorphisms (MTHFR C677T, MTHFR A1298C, Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G) and RPL risk in the Iranian population. PubMed, Web of Science, Google Scholar, and ISC were searched for eligible articles published up to April 1, 2017. In total, 37 case-control studies in 18 relevant publications were selected: 1,199, 1,194, 630, 830, and 955 RPL cases and 1,079, 1079, 594, 794, and 499 controls for MTHFR C677T, MTHFR A1298C,Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G, respectively. The results indicated a significant increased risk of RPL in all genetic models in the population. Also, Prothrombin G20210A and FVL G1691A as well as PAI-1 4G/5G polymorphisms were associated with RPL risk in the Iranian population. Hence, thrombophilic genes polymorphisms are associated with an increased RPL risk in the Iranian population. Pasteur Institute 2018-03 /pmc/articles/PMC5786662/ /pubmed/28734273 http://dx.doi.org/10.22034/ibj.22.2.78 Text en Copyright: © Iranian Biomedical Journal http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kamali, Mahdieh
Hantoushzadeh, Sedigheh
Borna, Sedigheh
Neamatzadeh, Hossein
Mazaheri, Mahta
Noori-Shadkam, Mahmood
Haghighi, Fatemeh
Association between Thrombophilic Genes Polymorphisms and Recurrent Pregnancy Loss Susceptibility in the Iranian Population: a Systematic Review and Meta-Analysis
title Association between Thrombophilic Genes Polymorphisms and Recurrent Pregnancy Loss Susceptibility in the Iranian Population: a Systematic Review and Meta-Analysis
title_full Association between Thrombophilic Genes Polymorphisms and Recurrent Pregnancy Loss Susceptibility in the Iranian Population: a Systematic Review and Meta-Analysis
title_fullStr Association between Thrombophilic Genes Polymorphisms and Recurrent Pregnancy Loss Susceptibility in the Iranian Population: a Systematic Review and Meta-Analysis
title_full_unstemmed Association between Thrombophilic Genes Polymorphisms and Recurrent Pregnancy Loss Susceptibility in the Iranian Population: a Systematic Review and Meta-Analysis
title_short Association between Thrombophilic Genes Polymorphisms and Recurrent Pregnancy Loss Susceptibility in the Iranian Population: a Systematic Review and Meta-Analysis
title_sort association between thrombophilic genes polymorphisms and recurrent pregnancy loss susceptibility in the iranian population: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786662/
https://www.ncbi.nlm.nih.gov/pubmed/28734273
http://dx.doi.org/10.22034/ibj.22.2.78
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