Cargando…

Extreme Drug Tolerance of Mycobacterium tuberculosis in Caseum

Tuberculosis (TB) recently became the leading infectious cause of death in adults, while attempts to shorten therapy have largely failed. Dormancy, persistence, and drug tolerance are among the factors driving the long therapy duration. Assays to measure in situ drug susceptibility of Mycobacterium...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sarathy, Jansy P., Via, Laura E., Weiner, Danielle, Blanc, Landry, Boshoff, Helena, Eugenin, Eliseo A., Barry, Clifton E., Dartois, Véronique A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786764/ https://www.ncbi.nlm.nih.gov/pubmed/29203492 http://dx.doi.org/10.1128/AAC.02266-17

Ejemplares similares

A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum
por: Sarathy, Jansy P., et al.
Publicado: (2023)

ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant M. abscessus in caseum surrogate
por: Xie, Min, et al.
Publicado: (2023)

The Role of Transport Mechanisms in Mycobacterium Tuberculosis Drug Resistance and Tolerance
por: Sarathy, Jansy Passiflora, et al.
Publicado: (2012)

Lesion Penetration and Activity Limit the Utility of Second-Line Injectable Agents in Pulmonary Tuberculosis
por: Ernest, Jacqueline P., et al.
Publicado: (2021)

Ethambutol Partitioning in Tuberculous Pulmonary Lesions Explains Its Clinical Efficacy
por: Zimmerman, Matthew, et al.
Publicado: (2017)

Polyamines Inhibit Porin-Mediated Fluoroquinolone Uptake in Mycobacteria
por: Sarathy, Jansy Passiflora, et al.
Publicado: (2013)

Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations
por: Sarathy, Jansy, et al.
Publicado: (2019)

CinA mediates multidrug tolerance in Mycobacterium tuberculosis
por: Kreutzfeldt, Kaj M., et al.
Publicado: (2022)

On-Slide Heat Sterilization Enables Mass Spectrometry Imaging of Tissue Infected with High-Threat Pathogens Outside of Biocontainment: A Study Directed at Mycobacterium tuberculosis
por: Wang, Ning, et al.
Publicado: (2021)

Tissue Distribution of Doxycycline in Animal Models of Tuberculosis
por: Gengenbacher, Martin, et al.
Publicado: (2020)

In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1
por: Gopal, Pooja, et al.
Publicado: (2017)

Pharmacokinetics and Target Attainment of SQ109 in Plasma and Human-Like Tuberculosis Lesions in Rabbits
por: Egbelowo, Oluwaseun, et al.
Publicado: (2021)

Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach
por: Pienaar, Elsje, et al.
Publicado: (2017)

Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development
por: Beites, Tiago, et al.
Publicado: (2019)

Mycobacterium tuberculosis DprE1 Inhibitor OPC-167832 Is Active against Mycobacterium abscessus In Vitro
por: Sarathy, Jickky Palmae, et al.
Publicado: (2022)

Blocking Bacterial Naphthohydroquinone Oxidation and ADP-Ribosylation Improves Activity of Rifamycins against Mycobacterium abscessus
por: Ganapathy, Uday S., et al.
Publicado: (2021)

The association between sterilizing activity and drug distribution into tuberculosis lesions
por: Prideaux, Brendan, et al.
Publicado: (2015)

Fumarate Reductase Activity Maintains an Energized Membrane in Anaerobic Mycobacterium tuberculosis
por: Watanabe, Shinya, et al.
Publicado: (2011)

Impact of immunopathology on the antituberculous activity of pyrazinamide
por: Blanc, Landry, et al.
Publicado: (2018)

TBAJ-876, a 3,5-Dialkoxypyridine Analogue of Bedaquiline, Is Active against Mycobacterium abscessus
por: Sarathy, Jickky Palmae, et al.
Publicado: (2020)

Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses
por: Lenaerts, Anne, et al.
Publicado: (2015)

Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas
por: Cicchese, Joseph M., et al.
Publicado: (2020)

Lung microenvironments harbor Mycobacterium tuberculosis phenotypes with distinct treatment responses
por: Walter, Nicholas D., et al.
Publicado: (2023)

Rv2607 from Mycobacterium tuberculosis Is a Pyridoxine 5′-Phosphate Oxidase with Unusual Substrate Specificity
por: Mashalidis, Ellene H., et al.
Publicado: (2011)

Visualization of Mycobacterial Biomarkers and Tuberculosis Drugs in Infected Tissue by MALDI-MS Imaging
por: Blanc, Landry, et al.
Publicado: (2018)

SAR and identification of 2-(quinolin-4-yloxy)acetamides as Mycobacterium tuberculosis cytochrome bc (1) inhibitors
por: Phummarin, Narisa, et al.
Publicado: (2016)

A novel F(420)-dependent anti-oxidant mechanism protects Mycobacterium tuberculosis against oxidative stress and bactericidal agents
por: Gurumurthy, Meera, et al.
Publicado: (2013)

Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance
por: Arastehfar, Amir, et al.
Publicado: (2023)

Extreme Drug Tolerance of Mycobacterium abscessus “Persisters”
por: Yam, Yee-Kuen, et al.
Publicado: (2020)

Inflammatory signaling in human Tuberculosis granulomas is spatially organized
por: Marakalala, Mohlopheni J., et al.
Publicado: (2016)

Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis
por: Evans, Joanna C., et al.
Publicado: (2016)

Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs
por: Shi, Lanbo, et al.
Publicado: (2015)

Development and Optimization of Chromosomally-Integrated Fluorescent Mycobacterium tuberculosis Reporter Constructs
por: Kolbe, Katharina, et al.
Publicado: (2020)

Storage lipid studies in tuberculosis reveal that foam cell biogenesis is disease-specific
por: Guerrini, Valentina, et al.
Publicado: (2018)

Evaluating the Sensitivity of Mycobacterium tuberculosis to Biotin Deprivation Using Regulated Gene Expression
por: Woong Park, Sae, et al.
Publicado: (2011)

Characterization of In Vitro Resistance to Linezolid in Mycobacterium abscessus
por: Negatu, Dereje A., et al.
Publicado: (2023)

Editorial: Drug-resistant Mycobacterium tuberculosis
por: Boshoff, Helena I. M., et al.
Publicado: (2023)

Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo
por: Liu, Yancheng, et al.
Publicado: (2016)

Tuberculosis Drug Discovery: A Decade of Hit Assessment for Defined Targets
por: Oh, Sangmi, et al.
Publicado: (2021)

Community-acquired pneumonia infections by Acinetobacter baumannii: How does alcohol impact the antimicrobial functions of macrophages?
por: Eugenin, Eliseo A
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_vb84g5qkqkgk6b79724mkg9dag