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Body mass index as a risk factor for coronary events and mortality in patients with type 1 diabetes

OBJECTIVE: To investigate the potential relationship between body mass index (BMI) and the risk for myocardial infarction and coronary death in patients with type 1 diabetes. METHODS: We studied patients with type 1 diabetes included in the Swedish National Diabetes Registry during 2002–2004 and fol...

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Autores principales: Vestberg, Daniel, Rosengren, Annika, Eeg-Olofsson, Katarina, Miftaraj, Mervete, Franzen, Stefan, Svensson, Ann-Marie, Lind, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786904/
https://www.ncbi.nlm.nih.gov/pubmed/29387430
http://dx.doi.org/10.1136/openhrt-2017-000727
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author Vestberg, Daniel
Rosengren, Annika
Eeg-Olofsson, Katarina
Miftaraj, Mervete
Franzen, Stefan
Svensson, Ann-Marie
Lind, Marcus
author_facet Vestberg, Daniel
Rosengren, Annika
Eeg-Olofsson, Katarina
Miftaraj, Mervete
Franzen, Stefan
Svensson, Ann-Marie
Lind, Marcus
author_sort Vestberg, Daniel
collection PubMed
description OBJECTIVE: To investigate the potential relationship between body mass index (BMI) and the risk for myocardial infarction and coronary death in patients with type 1 diabetes. METHODS: We studied patients with type 1 diabetes included in the Swedish National Diabetes Registry during 2002–2004 and followed them until a discharge diagnosis for myocardial infarction, acute coronary event, death or until 31 December 2011. Cox regression was used to estimate relative risks. RESULTS: In 17 499 patients with type 1 diabetes (mean age 39.4 years; mean BMI 25.2 kg/m(2)), 819 were diagnosed with myocardial infarction as a primary or secondary diagnosis during a mean follow-up of 8.5 years (maximum 9.9 years). Estimated with Cox regression, there was no significant effect of increased BMI on the risk of myocardial infarction (HR 1.4 (95% CI 0.7 to 2.5) in the group with BMI >35 kg/m(2) compared with BMI 18.5–25 kg/m(2). There was no association between BMI and coronary mortality, acute coronary events or all-cause mortality after adjusting for other known risk factors. Underweight patients (BMI <18.5 kg/m(2)) had increased hazard for coronary (HR 5.0 (95% CI 1.5 to 16.9)) and all-cause mortality (HR 5.4 (95% CI 3.1 to 9.6)) compared with BMI 18.5–25 kg/m(2). CONCLUSIONS: Among patients with type 1 diabetes, increased BMI is not a significant independent risk factor for myocardial infarction or coronary death after adjustment for other risk factors. Low BMI (less than 18.5 kg/m(2)) is associated with mortality from coronary or any cause.
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spelling pubmed-57869042018-01-31 Body mass index as a risk factor for coronary events and mortality in patients with type 1 diabetes Vestberg, Daniel Rosengren, Annika Eeg-Olofsson, Katarina Miftaraj, Mervete Franzen, Stefan Svensson, Ann-Marie Lind, Marcus Open Heart Cardiac Risk Factors and Prevention OBJECTIVE: To investigate the potential relationship between body mass index (BMI) and the risk for myocardial infarction and coronary death in patients with type 1 diabetes. METHODS: We studied patients with type 1 diabetes included in the Swedish National Diabetes Registry during 2002–2004 and followed them until a discharge diagnosis for myocardial infarction, acute coronary event, death or until 31 December 2011. Cox regression was used to estimate relative risks. RESULTS: In 17 499 patients with type 1 diabetes (mean age 39.4 years; mean BMI 25.2 kg/m(2)), 819 were diagnosed with myocardial infarction as a primary or secondary diagnosis during a mean follow-up of 8.5 years (maximum 9.9 years). Estimated with Cox regression, there was no significant effect of increased BMI on the risk of myocardial infarction (HR 1.4 (95% CI 0.7 to 2.5) in the group with BMI >35 kg/m(2) compared with BMI 18.5–25 kg/m(2). There was no association between BMI and coronary mortality, acute coronary events or all-cause mortality after adjusting for other known risk factors. Underweight patients (BMI <18.5 kg/m(2)) had increased hazard for coronary (HR 5.0 (95% CI 1.5 to 16.9)) and all-cause mortality (HR 5.4 (95% CI 3.1 to 9.6)) compared with BMI 18.5–25 kg/m(2). CONCLUSIONS: Among patients with type 1 diabetes, increased BMI is not a significant independent risk factor for myocardial infarction or coronary death after adjustment for other risk factors. Low BMI (less than 18.5 kg/m(2)) is associated with mortality from coronary or any cause. BMJ Publishing Group 2018-01-20 /pmc/articles/PMC5786904/ /pubmed/29387430 http://dx.doi.org/10.1136/openhrt-2017-000727 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Cardiac Risk Factors and Prevention
Vestberg, Daniel
Rosengren, Annika
Eeg-Olofsson, Katarina
Miftaraj, Mervete
Franzen, Stefan
Svensson, Ann-Marie
Lind, Marcus
Body mass index as a risk factor for coronary events and mortality in patients with type 1 diabetes
title Body mass index as a risk factor for coronary events and mortality in patients with type 1 diabetes
title_full Body mass index as a risk factor for coronary events and mortality in patients with type 1 diabetes
title_fullStr Body mass index as a risk factor for coronary events and mortality in patients with type 1 diabetes
title_full_unstemmed Body mass index as a risk factor for coronary events and mortality in patients with type 1 diabetes
title_short Body mass index as a risk factor for coronary events and mortality in patients with type 1 diabetes
title_sort body mass index as a risk factor for coronary events and mortality in patients with type 1 diabetes
topic Cardiac Risk Factors and Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786904/
https://www.ncbi.nlm.nih.gov/pubmed/29387430
http://dx.doi.org/10.1136/openhrt-2017-000727
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