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Sequential HER2 blockade as effective therapy in chemorefractory, HER2 gene-amplified, RAS wild-type, metastatic colorectal cancer: learning from a clinical case

BACKGROUND: Constitutive activation of HER2-dependent intracellular signalling by HER2 gene amplification or by HER2 mutations has been demonstrated as a mechanism of primary and secondary cancer resistance to cetuximab or panitumumab in preclinical and clinical models of metastatic colorectal cance...

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Detalles Bibliográficos
Autores principales:	Martinelli, Erika, Troiani, Teresa, Sforza, Vincenzo, Martini, Giulia, Cardone, Claudia, Vitiello, Pietro Paolo, Ciardiello, Davide, Rachiglio, Anna Maria, Normanno, Nicola, Sartore-Bianchi, Andrea, Marsoni, Silvia, Bardelli, Alberto, Siena, Salvatore, Ciardiello, Fortunato
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786925/ https://www.ncbi.nlm.nih.gov/pubmed/29387480 http://dx.doi.org/10.1136/esmoopen-2017-000299

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