Organelle luminal dependence of (+)strand RNA virus replication reveals a hidden druggable target

Positive-strand RNA viruses replicate their genomes in membrane-bounded cytoplasmic complexes. We show that endoplasmic reticulum (ER)–linked genomic RNA replication by brome mosaic virus (BMV), a well-studied member of the alphavirus superfamily, depends on the ER luminal thiol oxidase ERO1. We fur...

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Detalles Bibliográficos
Autores principales: Nishikiori, Masaki, Ahlquist, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787378/
https://www.ncbi.nlm.nih.gov/pubmed/29387794
http://dx.doi.org/10.1126/sciadv.aap8258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787378/
https://www.ncbi.nlm.nih.gov/pubmed/29387794
http://dx.doi.org/10.1126/sciadv.aap8258

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