Splice variants of the endonucleases XPF and XPG contain residual DNA repair capabilities and could be a valuable tool for personalized medicine

The two endonucleases XPF and XPG are essentially involved in nucleotide excision repair (NER) and interstrand crosslink (ICL) repair. Defects in these two proteins result in severe diseases like xeroderma pigmentosum (XP). We applied our newly CRISPR/Cas9 generated human XPF knockout cell line with...

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Detalles Bibliográficos
Autores principales: Lehmann, Janin, Schubert, Steffen, Seebode, Christina, Apel, Antje, Ohlenbusch, Andreas, Emmert, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787415/
https://www.ncbi.nlm.nih.gov/pubmed/29416673
http://dx.doi.org/10.18632/oncotarget.23105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787415/
https://www.ncbi.nlm.nih.gov/pubmed/29416673
http://dx.doi.org/10.18632/oncotarget.23105

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