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Chinese C allele carriers of the ERCC5 rs1047768 polymorphism are more sensitive to platinum-based chemotherapy: a meta-analysis
It is suspected that ERCC5 rs1047768 and rs17655 polymorphisms influence the response to platinum-based chemotherapy. This meta-analysis was performed to summarize the scattered evidence regarding the association between these two polymorphisms and sensitivity to platinum-based treatment. Thirteen s...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787435/ https://www.ncbi.nlm.nih.gov/pubmed/29416691 http://dx.doi.org/10.18632/oncotarget.18981 |
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author | Xu, Meizhen Liu, Yina Li, Dan Wang, Xuelin Liang, Shuang Zhang, Gaochuan Yang, Xiaoqin |
author_facet | Xu, Meizhen Liu, Yina Li, Dan Wang, Xuelin Liang, Shuang Zhang, Gaochuan Yang, Xiaoqin |
author_sort | Xu, Meizhen |
collection | PubMed |
description | It is suspected that ERCC5 rs1047768 and rs17655 polymorphisms influence the response to platinum-based chemotherapy. This meta-analysis was performed to summarize the scattered evidence regarding the association between these two polymorphisms and sensitivity to platinum-based treatment. Thirteen studies were included after a comprehensive literature search. The pooled odds ratios and 95% confidence intervals suggested that the C allele of the ERCC5 rs1047768 polymorphism is associated with elevated sensitivity to platinating agents, especially for Chinese patients. However, no difference among rs17655 genotypes could be detected. |
format | Online Article Text |
id | pubmed-5787435 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57874352018-02-07 Chinese C allele carriers of the ERCC5 rs1047768 polymorphism are more sensitive to platinum-based chemotherapy: a meta-analysis Xu, Meizhen Liu, Yina Li, Dan Wang, Xuelin Liang, Shuang Zhang, Gaochuan Yang, Xiaoqin Oncotarget Meta-Analysis It is suspected that ERCC5 rs1047768 and rs17655 polymorphisms influence the response to platinum-based chemotherapy. This meta-analysis was performed to summarize the scattered evidence regarding the association between these two polymorphisms and sensitivity to platinum-based treatment. Thirteen studies were included after a comprehensive literature search. The pooled odds ratios and 95% confidence intervals suggested that the C allele of the ERCC5 rs1047768 polymorphism is associated with elevated sensitivity to platinating agents, especially for Chinese patients. However, no difference among rs17655 genotypes could be detected. Impact Journals LLC 2017-07-04 /pmc/articles/PMC5787435/ /pubmed/29416691 http://dx.doi.org/10.18632/oncotarget.18981 Text en Copyright: © 2018 Xu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Meta-Analysis Xu, Meizhen Liu, Yina Li, Dan Wang, Xuelin Liang, Shuang Zhang, Gaochuan Yang, Xiaoqin Chinese C allele carriers of the ERCC5 rs1047768 polymorphism are more sensitive to platinum-based chemotherapy: a meta-analysis |
title | Chinese C allele carriers of the ERCC5 rs1047768 polymorphism are more sensitive to platinum-based chemotherapy: a meta-analysis |
title_full | Chinese C allele carriers of the ERCC5 rs1047768 polymorphism are more sensitive to platinum-based chemotherapy: a meta-analysis |
title_fullStr | Chinese C allele carriers of the ERCC5 rs1047768 polymorphism are more sensitive to platinum-based chemotherapy: a meta-analysis |
title_full_unstemmed | Chinese C allele carriers of the ERCC5 rs1047768 polymorphism are more sensitive to platinum-based chemotherapy: a meta-analysis |
title_short | Chinese C allele carriers of the ERCC5 rs1047768 polymorphism are more sensitive to platinum-based chemotherapy: a meta-analysis |
title_sort | chinese c allele carriers of the ercc5 rs1047768 polymorphism are more sensitive to platinum-based chemotherapy: a meta-analysis |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787435/ https://www.ncbi.nlm.nih.gov/pubmed/29416691 http://dx.doi.org/10.18632/oncotarget.18981 |
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