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Chinese C allele carriers of the ERCC5 rs1047768 polymorphism are more sensitive to platinum-based chemotherapy: a meta-analysis

It is suspected that ERCC5 rs1047768 and rs17655 polymorphisms influence the response to platinum-based chemotherapy. This meta-analysis was performed to summarize the scattered evidence regarding the association between these two polymorphisms and sensitivity to platinum-based treatment. Thirteen s...

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Detalles Bibliográficos
Autores principales: Xu, Meizhen, Liu, Yina, Li, Dan, Wang, Xuelin, Liang, Shuang, Zhang, Gaochuan, Yang, Xiaoqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787435/
https://www.ncbi.nlm.nih.gov/pubmed/29416691
http://dx.doi.org/10.18632/oncotarget.18981
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author Xu, Meizhen
Liu, Yina
Li, Dan
Wang, Xuelin
Liang, Shuang
Zhang, Gaochuan
Yang, Xiaoqin
author_facet Xu, Meizhen
Liu, Yina
Li, Dan
Wang, Xuelin
Liang, Shuang
Zhang, Gaochuan
Yang, Xiaoqin
author_sort Xu, Meizhen
collection PubMed
description It is suspected that ERCC5 rs1047768 and rs17655 polymorphisms influence the response to platinum-based chemotherapy. This meta-analysis was performed to summarize the scattered evidence regarding the association between these two polymorphisms and sensitivity to platinum-based treatment. Thirteen studies were included after a comprehensive literature search. The pooled odds ratios and 95% confidence intervals suggested that the C allele of the ERCC5 rs1047768 polymorphism is associated with elevated sensitivity to platinating agents, especially for Chinese patients. However, no difference among rs17655 genotypes could be detected.
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spelling pubmed-57874352018-02-07 Chinese C allele carriers of the ERCC5 rs1047768 polymorphism are more sensitive to platinum-based chemotherapy: a meta-analysis Xu, Meizhen Liu, Yina Li, Dan Wang, Xuelin Liang, Shuang Zhang, Gaochuan Yang, Xiaoqin Oncotarget Meta-Analysis It is suspected that ERCC5 rs1047768 and rs17655 polymorphisms influence the response to platinum-based chemotherapy. This meta-analysis was performed to summarize the scattered evidence regarding the association between these two polymorphisms and sensitivity to platinum-based treatment. Thirteen studies were included after a comprehensive literature search. The pooled odds ratios and 95% confidence intervals suggested that the C allele of the ERCC5 rs1047768 polymorphism is associated with elevated sensitivity to platinating agents, especially for Chinese patients. However, no difference among rs17655 genotypes could be detected. Impact Journals LLC 2017-07-04 /pmc/articles/PMC5787435/ /pubmed/29416691 http://dx.doi.org/10.18632/oncotarget.18981 Text en Copyright: © 2018 Xu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Meta-Analysis
Xu, Meizhen
Liu, Yina
Li, Dan
Wang, Xuelin
Liang, Shuang
Zhang, Gaochuan
Yang, Xiaoqin
Chinese C allele carriers of the ERCC5 rs1047768 polymorphism are more sensitive to platinum-based chemotherapy: a meta-analysis
title Chinese C allele carriers of the ERCC5 rs1047768 polymorphism are more sensitive to platinum-based chemotherapy: a meta-analysis
title_full Chinese C allele carriers of the ERCC5 rs1047768 polymorphism are more sensitive to platinum-based chemotherapy: a meta-analysis
title_fullStr Chinese C allele carriers of the ERCC5 rs1047768 polymorphism are more sensitive to platinum-based chemotherapy: a meta-analysis
title_full_unstemmed Chinese C allele carriers of the ERCC5 rs1047768 polymorphism are more sensitive to platinum-based chemotherapy: a meta-analysis
title_short Chinese C allele carriers of the ERCC5 rs1047768 polymorphism are more sensitive to platinum-based chemotherapy: a meta-analysis
title_sort chinese c allele carriers of the ercc5 rs1047768 polymorphism are more sensitive to platinum-based chemotherapy: a meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787435/
https://www.ncbi.nlm.nih.gov/pubmed/29416691
http://dx.doi.org/10.18632/oncotarget.18981
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